Drug Resistance of Different Mycobacterium tuberculosis Genotypes in the Omsk Oblast, Russia

Мұқаба

Дәйексөз келтіру

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Рұқсат жабық Тек жазылушылар үшін

Аннотация

A total of 397 Mycobacterium tuberculosis strains isolated from newly diagnosed patients with pulmonary tuberculosis in the Omsk region in 2019‒2020 were genotyped. The prevalence of strains of the Beijing genotype (70.8%) was established, in particular of two clusters of the modern sublineage — Central Asian/Russian (46.1%) and B0/W148 (19.1%). Strains of the ancient sublineage of the Beijing genotype were represented by clusters 1071-32 and 14717-15, totaling 4.8%. Compared with other genotypes, B0/W148 cluster and the ancient Beijing sublineage were associated with multidrug resistance (MDR): 93.4% and 94.7%, respectively (P < 0.0001). Among representatives of other genetic families (LAM, Ural, T, Haarlem), drug-sensitive strains predominated (75.0%). The circulation of MDR Beijing strains requires molecular epidemiological surveillance in view of their possible wider spread.

Толық мәтін

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Авторлар туралы

A. Vyazovaya

St. Petersburg Pasteur Institute

Хат алмасуға жауапты Автор.
Email: elmtree2001@mail.ru
Ресей, St. Petersburg, 197101

I. Kostyukova

Clinical Anti-tuberculosis Dispensary

Email: elmtree2001@mail.ru
Ресей, Omsk, 644058

A. Gerasimova

St. Petersburg Pasteur Institute

Email: elmtree2001@mail.ru
Ресей, St. Petersburg, 197101

D. Terentieva

St. Petersburg Pasteur Institute

Email: elmtree2001@mail.ru
Ресей, St. Petersburg, 197101

O. Pasechnik

Omsk State Medical University

Email: elmtree2001@mail.ru
Ресей, Omsk, 644099

I. Mokrousov

St. Petersburg Pasteur Institute

Email: elmtree2001@mail.ru
Ресей, St. Petersburg, 197101

Әдебиет тізімі

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