CORRECTION BY TAUCIN OF LIVER METABOLIС AND FUNCTIONAL LIVER DISTURBANCES IN RATS INROXICATED WITH PARACETAMOL
Pashko A., Borisenok O., Bushma M.
Resumo
The combination of taurine (50 g/mole, 6.25g) with zinc diaspartate (1 g/mole, 0.35g) named «taucine-50», administrated in the rat stomach (0.50 g/kg over 10 days )increases the paracetamol-inhibited (administrated in the stomach 2.50 g/kg over 5 days) activity of succinate dehydrogenase, lactate dehydrogenase (LDH), nicotinamine adenine nucleotide – dehydrogenase (NADH) and acidic phosphatase (ACPH) in the rat liver and decreases in plasma an increased activity of alanine aminotransferase (ALT), aspartate aminotransferase (AspAT) and alkaline phosphatase (ALP) as well as elevated content of total bilirubin, its conjugated forms and cholesterol. Hepatoprotective effect of «taucin-20» (0.5 g/kg/day) is less pronounced.