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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Digital Diagnostics</journal-id><journal-title-group><journal-title xml:lang="en">Digital Diagnostics</journal-title><trans-title-group xml:lang="ru"><trans-title>Digital Diagnostics</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Digital Diagnostics</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2712-8490</issn><issn publication-format="electronic">2712-8962</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">472068</article-id><article-id pub-id-type="doi">10.17816/DD472068</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Case reports</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические случаи и серии клинических случаев</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="zh"><subject>临床病例及临床病例的系列</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Computed tomography in the diagnosis of fever of unknown origin: A case report</article-title><trans-title-group xml:lang="ru"><trans-title>Компьютерная томография в диагностике лихорадки неясного генеза: описание случая</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>电子计算机断层扫描在不明原因发热诊断中的应用：病例描述</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8521-4045</contrib-id><contrib-id contrib-id-type="spin">3164-5518</contrib-id><name-alternatives><name xml:lang="en"><surname>Shumskaya</surname><given-names>Yuliya F.</given-names></name><name xml:lang="ru"><surname>Шумская</surname><given-names>Юлия Федоровна</given-names></name><name xml:lang="zh"><surname>Shumskaya</surname><given-names>Yuliya F.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>ShumskayaYF@zdrav.mos.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3509-7271</contrib-id><contrib-id contrib-id-type="spin">7962-4554</contrib-id><name-alternatives><name xml:lang="en"><surname>Kostikova</surname><given-names>Nina V.</given-names></name><name xml:lang="ru"><surname>Костикова</surname><given-names>Нина Владимировна</given-names></name><name xml:lang="zh"><surname>Kostikova</surname><given-names>Nina V.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>n.kostikowa@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7705-9754</contrib-id><contrib-id contrib-id-type="spin">6983-5991</contrib-id><name-alternatives><name xml:lang="en"><surname>Akhmedzyanova</surname><given-names>Dina A.</given-names></name><name xml:lang="ru"><surname>Ахмедзянова</surname><given-names>Дина Альфредовна</given-names></name><name xml:lang="zh"><surname>Akhmedzyanova</surname><given-names>Dina A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>dina_akhm@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5776-2693</contrib-id><contrib-id contrib-id-type="spin">7193-6122</contrib-id><name-alternatives><name xml:lang="en"><surname>Suleymanova</surname><given-names>Maria M.</given-names></name><name xml:lang="ru"><surname>Сулейманова</surname><given-names>Мария Мирославовна</given-names></name><name xml:lang="zh"><surname>Suleymanova</surname><given-names>Maria M.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>ashe.danny.jush@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3733-4381</contrib-id><name-alternatives><name xml:lang="en"><surname>Fominykh</surname><given-names>Ekaterina V.</given-names></name><name xml:lang="ru"><surname>Фоминых</surname><given-names>Екатерина Викторовна</given-names></name><name xml:lang="zh"><surname>Fominykh</surname><given-names>Ekaterina V.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci (Med.), Head of the Radiology Department</p></bio><bio xml:lang="ru"><p>к.м.н., зав. отделением лучевой диагностики</p></bio><bio xml:lang="zh"><p>Cand. Sci (Med.), Head of the Radiology Department</p></bio><email>evfominykh@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9337-7453</contrib-id><contrib-id contrib-id-type="spin">2015-1822</contrib-id><name-alternatives><name xml:lang="en"><surname>Mnatsakanyan</surname><given-names>Marina G.</given-names></name><name xml:lang="ru"><surname>Мнацаканян</surname><given-names>Марина Генриковна</given-names></name><name xml:lang="zh"><surname>Mnatsakanyan</surname><given-names>Marina G.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Med), Professor</p></bio><email>mnatsakanyan08@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9661-0254</contrib-id><contrib-id contrib-id-type="spin">8592-0558</contrib-id><name-alternatives><name xml:lang="en"><surname>Reshetnikov</surname><given-names>Roman V.</given-names></name><name xml:lang="ru"><surname>Решетников</surname><given-names>Роман Владимирович</given-names></name><name xml:lang="zh"><surname>Reshetnikov</surname><given-names>Roman V.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Phys.-Math.)</p></bio><bio xml:lang="ru"><p>канд. физ.-мат. наук</p></bio><bio xml:lang="zh"><p>Cand. Sci. (Phys.-Math.)</p></bio><email>reshetnikov@fbb.msu.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies</institution></aff><aff><institution xml:lang="ru">Научно-практический клинический центр диагностики и телемедицинских технологий</institution></aff><aff><institution xml:lang="zh">Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">The First Sechenov Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution></aff><aff><institution xml:lang="zh">The First Sechenov Moscow State Medical University (Sechenov University)</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2023-08-23" publication-format="electronic"><day>23</day><month>08</month><year>2023</year></pub-date><pub-date date-type="pub" iso-8601-date="2023-09-26" publication-format="electronic"><day>26</day><month>09</month><year>2023</year></pub-date><volume>4</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>393</fpage><lpage>402</lpage><history><date date-type="received" iso-8601-date="2023-06-02"><day>02</day><month>06</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-07-04"><day>04</day><month>07</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Эко-вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2023, Eco-Vector</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-вектор</copyright-holder><copyright-holder xml:lang="zh">Eco-Vector</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://jdigitaldiagnostics.com/DD/article/view/472068">https://jdigitaldiagnostics.com/DD/article/view/472068</self-uri><abstract xml:lang="en"><p>Fever of unknown origin can be a symptom of at least 200 diseases. Positron emission tomography-computed tomography, although highly informative, may not be readily available as an imaging tool. We present a clinical case of giant cell arteritis where computed tomography played a key role in arriving at a diagnosis.</p> <p>A 61-year-old woman presented to the hospital with a nocturnal fever up to 39.5°С, accompanied by chest and scapular pain, and substantial weight loss (10 kg over 3 months). Lymphoproliferative and infectious diseases were excluded. Baseline colonoscopy had revealed erosions in the colonic mucosa, leading to a preliminary diagnosis of ulcerative colitis, and subsequently, the patient was admitted to the gastroenterology department. Follow-up colonoscopy had excluded this diagnosis. Additional imaging via chest and abdominal computed tomography scan revealed wall thickening of aorta and its branches with subtle contrast enhancement.</p> <p>Conditions, such as tuberculous aortoarteritis and syphilitic aortitis, were excluded. The patient was diagnosed with giant cell arteritis involving brachiocephalic trunk, subclavian arteries, and celiac trunk. Prednisolone was administered with subsequent reduction in symptoms.</p> <p>Although computed tomography may not be regarded as the gold standard for the differential diagnosis of fever of unknown origin, this case underscores its valuable contribution in establishing a definitive diagnosis.</p></abstract><trans-abstract xml:lang="ru"><p>Под маской лихорадки неясного генеза могут протекать более двухсот заболеваний. Позитронно-эмиссионная томография, совмещённая с компьютерной томографией, является информативным, но не всегда доступным методом диагностики причин лихорадки неясного генеза. В данной работе представлен случай пациентки с лихорадкой неясного генеза, у которой данные компьютерной томографии сыграли ключевую роль в диагностике гигантоклеточного артериита.</p> <p>Пациентка, 61 год, с жалобами на повышение температуры тела в вечерние часы до 39,5°С, боли в прекардиальной и межлопаточной областях, снижение массы тела на 10 кг за 3 месяца. В рамках дифференциально-диагностического поиска исключены инфекционные и лимфопролиферативные заболевания. Как причина лихорадки неясного генеза рассматривался эрозивный колит, ранее выявленный при эндоскопическом исследовании, по поводу чего пациентка была госпитализирована в гастроэнтерологическое отделение. При повторной колоноскопии наблюдалась нормальная эндоскопическая картина. По данным компьютерной томографии органов грудной клетки и брюшной полости с внутривенным контрастированием выявлено выраженное утолщение стенок аорты и её ветвей с активным накоплением контрастного вещества, что являлось отражением высокоактивного артериита. В рамках дополнительного обследования исключён специфический артериит. Диагноз сформулирован как гигантоклеточный артериит с поражением брахиоцефального ствола, подключичных артерий, чревного ствола. Пациентке назначен преднизолон с последующим регрессом клинической симптоматики.</p> <p>Несмотря на то, что компьютерная томография не является золотым стандартом в диагностике лихорадки неясного генеза, применение данного метода в рамках комплексного обследования позволило установить окончательный диагноз пациентке с неклассическим течением гигантоклеточного артериита и длительно существующей лихорадкой неясного генеза.</p></trans-abstract><trans-abstract xml:lang="zh"><p>有两百多种疾病可以在不明原因发热的掩盖下发生。正电子发射断层扫描结合电子计算机断层扫描是诊断不明原因发热的一种信息丰富但并非总是可用的方法。本文介绍一例不明原因发热的女性患者，CT数据在她巨细胞动脉炎的诊断中发挥了关键作用。</p> <p>一名61岁的女性患者，主诉傍晚体温升高至39.5ºC，心前区和肩胛间区疼痛，体重在3个月内下降了10kg。在进行鉴别诊断时，排除了感染性疾病和淋巴增生性疾病。作为不明原因发热的原因，考虑了溃疡性结肠炎，该病曾在内窥镜检查中被发现，患者因此在消化科住院治疗。再次结肠镜检查显示了，内窥镜检查结果正常。通过静脉注射造影剂对胸腔和腹腔进行了电子计算机断层扫描，发现了主动脉及其分支的管壁明显增厚，造影剂积聚活跃，这反映了高度活跃的动脉炎。其他检查排除了特异性动脉炎。诊断结果为巨细胞动脉炎，并累及头臂干、锁骨下动脉和腹腔動脈干。医生给病人开了泼尼松龙，随后临床症状有所缓解。</p> <p>虽然电子计算机断层扫描不是诊断不明原因发热的金标准，但在综合检查框架内使用这种方法，最终允许了对一名患有非典型巨细胞动脉炎病程和长期不明原因发热的患者确诊。</p></trans-abstract><kwd-group xml:lang="en"><kwd>fever of unknown origin</kwd><kwd>tomography</kwd><kwd>X-ray computed</kwd><kwd>giant cell arteritis</kwd><kwd>case report</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>лихорадка неясного генеза</kwd><kwd>компьютерная томография</kwd><kwd>гигантоклеточный артериит</kwd><kwd>описание случая</kwd></kwd-group><kwd-group xml:lang="zh"><kwd>不明原因的发热</kwd><kwd>电子计算机断层扫描</kwd><kwd>巨细胞动脉炎</kwd><kwd>病例描述</kwd></kwd-group><funding-group><funding-statement xml:lang="en">This article was prepared by a group of authors as a part of the research and development effort titled “Opportunistic screening of high-profile and other common diseases”, No. 123031400009-1 (USIS No. 123031400009-1) in accordance with the Order No. 1196 dated December 21, 2022 “On approval of state assignments funded by means of allocations from the budget of the city of Moscow to the state budgetary (autonomous) institutions subordinate to the Moscow Health Care Department, for 2023 and the planned period of 2024 and 2025” issued by the Moscow Health Care Department</funding-statement><funding-statement xml:lang="ru">Данная статья подготовлена авторским коллективом в рамках НИР «Оппортунистический скрининг социально значимых и иных распространённых заболеваний» (№ ЕГИСУ: № 123031400009-1) в соответствии с приказом Департамента здравоохранения города Москвы от 21.12.2022 № 1196 «Об утверждении государственных заданий, финансовое обеспечение которых осуществляется за счет средств бюджета города Москвы, государственным бюджетным (автономным) учреждениям, подведомственным Департаменту здравоохранения города Москвы, на 2023 год и плановый период 2024 и 2025 годов»</funding-statement><funding-statement xml:lang="zh">This article was prepared by a group of authors as a part of the research and development effort titled “Opportunistic screening of high-profile and other common diseases”, No. 123031400009-1 (USIS No. 123031400009-1) in accordance with the Order No. 1196 dated December 21, 2022 “On approval of state assignments funded by means of allocations from the budget of the city of Moscow to the state budgetary (autonomous) institutions subordinate to the Moscow Health Care Department, for 2023 and the planned period of 2024 and 2025” issued by the Moscow Health Care Department</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Unger M, Karanikas G, Kerschbaumer A, et al. 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