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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Digital Diagnostics</journal-id><journal-title-group><journal-title xml:lang="en">Digital Diagnostics</journal-title><trans-title-group xml:lang="ru"><trans-title>Digital Diagnostics</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Digital Diagnostics</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2712-8490</issn><issn publication-format="electronic">2712-8962</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">631596</article-id><article-id pub-id-type="doi">10.17816/DD631596</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Научные обзоры</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="zh"><subject>科学评论</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The role of radiomics in diagnosing gastrointestinal stromal tumors: a review</article-title><trans-title-group xml:lang="ru"><trans-title>Возможности радиомики в диагностике гастроинтестинальных стромальных опухолей: научный обзор</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>胃肠道间质瘤的放射组学诊断潜力：科学综述</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1854-9638</contrib-id><contrib-id contrib-id-type="spin">8006-8917</contrib-id><name-alternatives><name xml:lang="en"><surname>Martirosyan</surname><given-names>Elina A.</given-names></name><name xml:lang="ru"><surname>Мартиросян</surname><given-names>Элина Арташесовна</given-names></name><name xml:lang="zh"><surname>Martirosyan</surname><given-names>Elina A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>robatik2009@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9357-0998</contrib-id><contrib-id contrib-id-type="spin">5964-2369</contrib-id><name-alternatives><name xml:lang="en"><surname>Karmazanovsky</surname><given-names>Grigory G.</given-names></name><name xml:lang="ru"><surname>Кармазановский</surname><given-names>Григорий Григорьевич</given-names></name><name xml:lang="zh"><surname>Karmazanovsky</surname><given-names>Grigory G.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor, academician of the Russian Academy of Sciences</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор, академик РАН</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Medicine), Professor, academician of the Russian Academy of Sciences</p></bio><email>karmazanovsky@ixv.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7070-3391</contrib-id><contrib-id contrib-id-type="spin">2702-6526</contrib-id><name-alternatives><name xml:lang="en"><surname>Kondratyev</surname><given-names>Evgeny V.</given-names></name><name xml:lang="ru"><surname>Кондратьев</surname><given-names>Евгений Валерьевич</given-names></name><name xml:lang="zh"><surname>Kondratyev</surname><given-names>Evgeny V.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine)</p></bio><email>kondratev@ixv.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5667-7833</contrib-id><contrib-id contrib-id-type="spin">9197-6568</contrib-id><name-alternatives><name xml:lang="en"><surname>Sokolova</surname><given-names>Elena A.</given-names></name><name xml:lang="ru"><surname>Соколова</surname><given-names>Елена Александровна</given-names></name><name xml:lang="zh"><surname>Sokolova</surname><given-names>Elena A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>elena83.sokolova@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6716-5593</contrib-id><contrib-id contrib-id-type="spin">2527-0130</contrib-id><name-alternatives><name xml:lang="en"><surname>Nechaev</surname><given-names>Valentin A.</given-names></name><name xml:lang="ru"><surname>Нечаев</surname><given-names>Валентин Александрович</given-names></name><name xml:lang="zh"><surname>Nechaev</surname><given-names>Valentin A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine)</p></bio><email>nechaevva1@zdrav.mos.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-2856-5176</contrib-id><contrib-id contrib-id-type="spin">9668-5733</contrib-id><name-alternatives><name xml:lang="en"><surname>Kuzmina</surname><given-names>Evgeniya S.</given-names></name><name xml:lang="ru"><surname>Кузьмина</surname><given-names>Евгения Сергеевна</given-names></name><name xml:lang="zh"><surname>Kuzmina</surname><given-names>Evgeniya S.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>kuz011@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6619-6179</contrib-id><contrib-id contrib-id-type="spin">3148-4843</contrib-id><name-alternatives><name xml:lang="en"><surname>Galkin</surname><given-names>Vsevolod N.</given-names></name><name xml:lang="ru"><surname>Галкин</surname><given-names>Всеволод Николаевич</given-names></name><name xml:lang="zh"><surname>Galkin</surname><given-names>Vsevolod N.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><email>galkinvn2@zdrav.mos.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6904-9318</contrib-id><contrib-id contrib-id-type="spin">4947-4382</contrib-id><name-alternatives><name xml:lang="en"><surname>Glotov</surname><given-names>Andrey V.</given-names></name><name xml:lang="ru"><surname>Глотов</surname><given-names>Андрей Вячеславович</given-names></name><name xml:lang="zh"><surname>Glotov</surname><given-names>Andrey V.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>andrew.glotov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">A.V. Vishnevsky National Medical Research Center of Surgery</institution></aff><aff><institution xml:lang="ru">Национальный медицинский исследовательский центр хирургии имени А.В. Вишневского</institution></aff><aff><institution xml:lang="zh">A.V. Vishnevsky National Medical Research Center of Surgery</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">S.S. Yudin City Clinical Hospital</institution></aff><aff><institution xml:lang="ru">Городская клиническая больница имени С.С. Юдина</institution></aff><aff><institution xml:lang="zh">S.S. Yudin City Clinical Hospital</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">The Russian National Research Medical University named N.I. Pirogov</institution></aff><aff><institution xml:lang="ru">Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution></aff><aff><institution xml:lang="zh">The Russian National Research Medical University named N.I. Pirogov</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2024-12-25" publication-format="electronic"><day>25</day><month>12</month><year>2024</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-03-25" publication-format="electronic"><day>25</day><month>03</month><year>2025</year></pub-date><volume>6</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>143</fpage><lpage>155</lpage><history><date date-type="received" iso-8601-date="2024-05-21"><day>21</day><month>05</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-06-20"><day>20</day><month>06</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-вектор</copyright-holder><copyright-holder xml:lang="zh">Eco-Vector</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://jdigitaldiagnostics.com/DD/article/view/631596">https://jdigitaldiagnostics.com/DD/article/view/631596</self-uri><abstract xml:lang="en"><p>Gastrointestinal stromal tumors are the most common mesenchymal neoplasms of the gastrointestinal tract originating from the interstitial cells of Cajal, accounting for approximately 80% of all primary gastric tumors. Despite their widespread use, traditional diagnostic methods for gastrointestinal stromal tumors, such as computed tomography, endoscopic examination, endoscopic ultrasound, and fine-needle aspiration biopsy, have several limitations, including diagnostic uncertainty and limited capabilities of biopsy.</p> <p>Radiomics, which involves analyzing texture features in medical images, is considered an innovative approach, with the potential to enhance diagnostic accuracy in gastrointestinal stromal tumors detection. This method allows for the interpretation of tissue changes through the mathematical processing of images, revealing information beyond the human eye’s ability to detect, which can be beneficial for the early detection of tumors.</p> <p>This article assesses the advantages and disadvantages of current methods for diagnosing gastrointestinal stromal tumors and the potential of radiomics to improve diagnostic outcomes. The review allows to determine the best applications and promising directions for future research in this crucial field.</p></abstract><trans-abstract xml:lang="ru"><p>Гастроинтестинальные стромальные опухоли — наиболее распространённые мезенхимальные новообразования желудочно-кишечного тракта, происходящие из интерстициальных клеток Кахаля и составляющие ~80% всех первичных опухолей желудка. Классические методы диагностики гастроинтестинальных стромальных опухолей, такие как компьютерная томография, эндоскопическое исследование, эндоскопическое ультразвуковое исследование и тонкоигольная аспирационная биопсия, несмотря на широкое применение, имеют ряд недостатков, включая диагностическую неопределённость и ограниченные возможности биопсии.</p> <p>Радиомику, представляющую собой анализ текстурных характеристик изображений, рассматривают в качестве инновационного метода, потенциально способного повысить точность диагностики гастроинтестинальных стромальных опухолей. Этот подход позволяет интерпретировать изменения в тканях за счёт математической обработки изображений, недоступной человеческому глазу, что может способствовать более точному выявлению опухолей на ранней стадии.</p> <p>В настоящей статье проведена оценка преимуществ и недостатков текущих методов диагностики гастроинтестинальных стромальных опухолей, а также потенциала радиомики в отношении улучшения результатов их диагностики. Обзор направлен на определение наилучших способов применения и перспективных направлений для будущих исследований в этой важной области.</p></trans-abstract><trans-abstract xml:lang="zh"><p>胃肠道间质瘤是最常见的胃肠道间叶性肿瘤，来源于卡哈尔氏间质细胞，约占所有胃部原发性肿瘤的80%。传统的胃肠道间质瘤诊断方法，如计算机断层扫描、内镜检查、内镜超声检查和细针穿刺活检，尽管被广泛应用，但仍存在一些缺点，包括诊断不确定性和活检的局限性。</p> <p>放射组学，作为图像纹理特征分析的创新方法，被认为有潜力提高胃肠道间质瘤的诊断精度。这种方法通过对图像的数学处理来解读组织中的变化，这是人眼无法直接看到的，从而有助于更早期地发现肿瘤。</p> <p>本文评估了当前胃肠道间质瘤诊断方法的优缺点，并探讨了放射组学在提高诊断效果方面的潜力。综述旨在确定最佳的应用方式和未来研究的前景方向。</p></trans-abstract><kwd-group xml:lang="en"><kwd>gastrointestinal stromal tumor</kwd><kwd>radiomics</kwd><kwd>diagnosis</kwd><kwd>computed tomography</kwd><kwd>radiogenomics</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>гастроинтестинальная стромальная опухоль</kwd><kwd>радиомика</kwd><kwd>диагностика</kwd><kwd>компьютерная томография</kwd><kwd>радиогеномика</kwd></kwd-group><kwd-group xml:lang="zh"><kwd>胃肠道间质瘤</kwd><kwd>放射组学</kwd><kwd>诊断</kwd><kwd>计算机断层扫描</kwd><kwd>放射基因组学</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Miettinen M, Lasota J. 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