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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Digital Diagnostics</journal-id><journal-title-group><journal-title xml:lang="en">Digital Diagnostics</journal-title><trans-title-group xml:lang="ru"><trans-title>Digital Diagnostics</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Digital Diagnostics</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2712-8490</issn><issn publication-format="electronic">2712-8962</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">634639</article-id><article-id pub-id-type="doi">10.17816/DD634639</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Научные обзоры</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="zh"><subject>科学评论</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Imaging techniques in diagnosing acute pulmonary thromboembolism</article-title><trans-title-group xml:lang="ru"><trans-title>Возможности методов визуализации в диагностике острой тромбоэмболии лёгочной артерии</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>肺动脉急性栓塞的影像学诊断方法的应用</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1896-023X</contrib-id><contrib-id contrib-id-type="spin">6531-2957</contrib-id><name-alternatives><name xml:lang="en"><surname>Oganesyan</surname><given-names>Anait A.</given-names></name><name xml:lang="ru"><surname>Оганесян</surname><given-names>Анаит Арамовна</given-names></name><name xml:lang="zh"><surname>Oganesyan</surname><given-names>Anait A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>talilen@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5649-2193</contrib-id><contrib-id contrib-id-type="spin">8449-6590</contrib-id><name-alternatives><name xml:lang="en"><surname>Sinitsyn</surname><given-names>Valentin E.</given-names></name><name xml:lang="ru"><surname>Синицын</surname><given-names>Валентин Евгеньевич</given-names></name><name xml:lang="zh"><surname>Sinitsyn</surname><given-names>Valentin E.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><email>vsini@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1266-4926</contrib-id><contrib-id contrib-id-type="spin">6897-9641</contrib-id><name-alternatives><name xml:lang="en"><surname>Mershina</surname><given-names>Elena A.</given-names></name><name xml:lang="ru"><surname>Мершина</surname><given-names>Елена Александровна</given-names></name><name xml:lang="zh"><surname>Mershina</surname><given-names>Elena A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine), Assistant Professor</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine), Assistant Professor</p></bio><email>Elena_Mershina@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3952-6865</contrib-id><contrib-id contrib-id-type="spin">7311-9276</contrib-id><name-alternatives><name xml:lang="en"><surname>Pershina</surname><given-names>Ekaterina S.</given-names></name><name xml:lang="ru"><surname>Першина</surname><given-names>Екатерина Сергеевна</given-names></name><name xml:lang="zh"><surname>Pershina</surname><given-names>Ekaterina S.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine)</p></bio><email>pershina@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Pirogov Municipal Clinical Hospital No. 1</institution></aff><aff><institution xml:lang="ru">Городская клиническая больница № 1 имени Н.И. Пирогова</institution></aff><aff><institution xml:lang="zh">Pirogov Municipal Clinical Hospital No. 1</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Lomonosov Moscow State University</institution></aff><aff><institution xml:lang="ru">Московский государственный университет имени М.В. Ломоносова</institution></aff><aff><institution xml:lang="zh">Lomonosov Moscow State University</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-02-19" publication-format="electronic"><day>19</day><month>02</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-03-25" publication-format="electronic"><day>25</day><month>03</month><year>2025</year></pub-date><volume>6</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>130</fpage><lpage>142</lpage><history><date date-type="received" iso-8601-date="2024-07-27"><day>27</day><month>07</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-11-21"><day>21</day><month>11</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-вектор</copyright-holder><copyright-holder xml:lang="zh">Eco-Vector</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://jdigitaldiagnostics.com/DD/article/view/634639">https://jdigitaldiagnostics.com/DD/article/view/634639</self-uri><abstract xml:lang="en"><p>Pulmonary thromboembolism is the occlusion of the pulmonary arteries by thrombi of any origin, which commonly originates in the large veins of the legs and pelvis. This article provides an overview of existing imaging techniques used in diagnosing this pathology. A review of scientific studies by Russian and international authors is provided. Moreover, the article discusses diagnostic algorithms and the characteristics and challenges of risk stratification in patients with suspected acute pulmonary thromboembolism. The key imaging aspects for this pathology and criteria for assessing its severity are highlighted. The contribution of relatively new perfusion tomography methods, such as dual-energy and subtraction computed tomography pulmonary angiography, and magnetic resonance pulmonary angiography is demonstrated. Despite the presence of established methods for diagnosing acute pulmonary embolism, there is growing interest in additional and alternative imaging techniques, which have been more integrated into routine clinical practice. Special attention is given to subtraction computed tomography pulmonary angiography, which has the ability to generate iodine maps for indirect perfusion assessment, and its application in clinical practice. The feasibility of using various imaging techniques in diagnosing acute pulmonary thromboembolism is discussed, highlighting their advantages and prospects in emergency medical care.</p></abstract><trans-abstract xml:lang="ru"><p>Тромбоэмболия лёгочной артерии — это окклюзия лёгочных артерий тромбами любого происхождения, чаще всего образующихся в крупных венах ног и малого таза. В статье представлен краткий обзор существующих методов визуализации в диагностике данной патологии. Проведён анализ научных работ отечественных и зарубежных авторов. Осуществлён обзор диагностических алгоритмов, особенностей и сложностей стратификации риска пациентов с подозрением на острую тромбоэмболию лёгочной артерии. Отмечены основные аспекты визуализации при данной патологии и критерии оценки её тяжести. Продемонстрирован вклад относительно новых перфузионных томографических методов диагностики, таких как двухэнергетическая и субтракционная компьютерно-томографическая ангиопульмонография, магнитно-резонансная ангиопульмонография. Несмотря на существующие традиционные методы диагностики острой тромбоэмболии лёгочной артерии, большой интерес вызывают дополнительные и альтернативные способы визуализации, которые всё больше укрепляются в ежедневной рутинной практике. Особое внимание уделяют методу субтракционной компьютерно-томографической ангиопульмонографии с возможностью построения йодных карт для косвенной оценки перфузии и его опыту применения в практике. Таким образом, рассмотрена целесообразность использования различных методов визуализации в диагностике острой тромбоэмболии лёгочной артерии с выделением преимуществ и их дальнейших перспектив в условиях экстренной медицинской помощи.</p></trans-abstract><trans-abstract xml:lang="zh"><p>肺动脉栓塞是由各种来源的血栓引起的肺动脉阻塞，通常源自下肢和盆腔的大型静脉。本文简要回顾了现有的影像学方法在诊断该病理中的应用，并分析了俄罗斯和国外学者的研究成果。文章回顾了急性肺动脉栓塞患者风险分层的诊断算法、特点及其难点，强调了该病理影像学诊断中的关键点以及评估其重症程度的标准。特别展示了新兴的通气血流影像学方法，如双能量计算机断层扫描肺动脉造影、减影计算机断层扫描肺动脉造影，以及磁共振肺动脉造影。尽管现有传统的急性肺动脉栓塞诊断方法依然广泛应用，但补充和替代性的影像学技术正在逐步成为日常临床工作的重要部分。尤其是减影计算机断层扫描肺动脉造影技术，它能够通过构建碘影像图来间接评估血流灌注，并且在临床实践中的应用经验不断丰富。因此，本文探讨了在急性肺动脉栓塞诊断中使用不同影像学方法的合理性，分析了这些方法的优势，并展望了它们在急救医学中的应用前景。</p></trans-abstract><kwd-group xml:lang="en"><kwd>acute pulmonary thromboembolism</kwd><kwd>dual-energy computed tomography pulmonary angiography</kwd><kwd>perfusion iodine maps</kwd><kwd>pulmonary artery</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>острая тромбоэмболия лёгочной артерии</kwd><kwd>двухэнергетическая компьютерно-томографическая ангиопульмонография</kwd><kwd>перфузионные йодные карты</kwd><kwd>лёгочная артерия</kwd></kwd-group><kwd-group xml:lang="zh"><kwd>急性肺动脉栓塞</kwd><kwd>双能量计算机断层扫描肺动脉造影</kwd><kwd>血流灌注碘影像图</kwd><kwd>肺动脉</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Vertkin AL, Gritsanchuk AM. Tromboembolism: an epidemic that everyone is silent about. The Russian Archives of Internal Medicine. 2014;(1):33–39. (In Russ.) doi: 10.20514/2226-6704-2014-0-1-33-39 EDN: TBCLKL</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Goldhaber SZ, Visani L, De Rosa M. Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER). The Lancet. 1999;353(9162):1386–1389. doi: 10.1016/S0140-6736(98)07534-5 EDN: DAROEL</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Kucher N, Rossi E, De Rosa M, Goldhaber SZ. Massive pulmonary embolism. Circulation. 2006;113(4):577–582. doi: 10.1161/CIRCULATIONAHA.105.592592</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Bajc M, Schümichen C, Grüning T, et al. EANM guideline for ventilation/perfusion single-photon emission computed tomography (SPECT) for diagnosis of pulmonary embolism and beyond. European Journal of Nuclear Medicine and Molecular Imaging. 2019;46(12):2429–2451. doi: 10.1007/s00259-019-04450-0 EDN: QGKIJW</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Mukhametshina GA, Amirov NB, Frolova EB, et al. The qustion of pulmonary artery tromboembolism. The Bulletin of Contemporary Clinical Medicine. 2013;6(4):67–73. EDN: RCKYBF</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Zhuravkov YuL, Koroleva AA. Modern principles of diagnosis and treatment of the acute pulmonary thromboembolism. Military Medicine. 2014;3(32):112–116. EDN: SLQPTP</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Sukhova MB, Trofimova TN. Modern aspects of MSCT diagnostics of acute massive pulmonary embolism. Diagnostic radiology and radiotherapy. 2021;12(4):7–14. doi: 10.22328/2079-5343-2021-12-4-7-14 EDN: OHOTRM</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Bokeriya LA, Zatevakhin II, Kirienko AI, et al. Russian clinical guidelines for the diagnosis, treatment and prevention of venous thromboembolic complications (VTEC). Flebologiya. 2015;9(4-2):1–52 (In Russ.) EDN: XIOPYZ</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Tyurin IE. Pulmonary embolism: possibilities of radiological diagnostics. Atmosfera. Pul'monologiya i allergologiya. 2005;(4):20–24 (In Russ.) EDN: OOPMTF</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Heit JA. Venous thromboembolism epidemiology: implications for prevention and management. Seminars in thrombosis and hemostasis. 2002;28 Suppl. 2:3–13. doi: 10.1055/s-2002-32312</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Sweet PH 3rd, Armstrong T, Chen J, et al. Fatal pulmonary embolism update: 10 years of autopsy experience at an academic medical center. JRSM Short Reports. 2013;4(9):2042533313489824. doi: 10.1177/2042533313489824</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Konstantinides SV, Meyer G, Becattini C, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonaryembolism developed in collaboration with the European Respiratory Society (ERS). Russian Journal of Cardiology. 2020;25(8):180–239. doi: 10.15829/1560-4071-2020-3848 EDN: NXTZZJ</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Ceriani E, Combescure C, Le Gal G, et al. Clinical prediction rules for pulmonary embolism: a systematic review and meta-analysis. Journal of Thrombosis and Haemostasis. 2010;8(5):957–970. doi: 10.1111/j.1538-7836.2010.03801.x</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Quezada CA, Bikdeli B, Barrios D, et al. Meta-analysis of prevalence and short-term prognosis of hemodynamically unstable patients with symptomatic acute pulmonary embolism. The American Journal of Cardiology. 2019;123(4):684–689. doi: 10.1016/j.amjcard.2018.11.009</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Singh R, Nie RZ, Homayounieh F, et al. Quantitative lobar pulmonary perfusion assessment on dual-energy CT pulmonary angiography: applications in pulmonary embolism. European Radiology. 2020;30(5):2535–2542. doi: 10.1007/s00330-019-06607-9 EDN: QVXDOT</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Tafur AJ, Shamoun FE, Patel SI, et al. Catheter-directed treatment of pulmonary embolism: a systematic review and meta-analysis of modern literature. Clinical and Applied Thrombosis/Hemostasis. 2016;23(7):821–829. doi: 10.1177/1076029616661414</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Kröger JR, Hickethier T, Pahn G, et al. Influence of spectral detector CT based monoenergetic images on the computer-aided detection of pulmonary artery embolism. European Journal of Radiology. 2017;95:242–248. doi: 10.1016/j.ejrad.2017.08.034</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Qanadli S, El Hajjam M, Vieillard-Baron A, et al. New CT index to quantify arterial obstruction in pulmonary embolism. American Journal of Roentgenology. 2001;176(6):1415–1420. doi: 10.2214/ajr.176.6.1761415</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Frank Peacock W, Coleman CI, Diercks DB, et al. Emergency department discharge of pulmonary embolus patients. Academic Emergency Medicine. 2018;25(9):995–1003. doi: 10.1111/acem.13451</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Torbicki A, Perrier A, Konstantinides S, et al. Guidelines on the diagnosis and management of acute pulmonary embolism: the task force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). European Heart Journal. 2008;29(18):2276–2315. doi: 10.1093/eurheartj/ehn310</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Giordano J, Khung S, Duhamel A, et al. Lung perfusion characteristics in pulmonary arterial hypertension (PAH) and peripheral forms of chronic thromboembolic pulmonary hypertension (pCTEPH): dual-energy CT experience in 31 patients. European Radiology. 2017;27(4):1631–1639. doi: 10.1007/s00330-016-4500-6 EDN: WXUBJW</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Pietersen PI, Goyard C, Gill T, et al. The CT revolution: the role of PIOPED II in establishing CT pulmonary angiography as the reference standard for pulmonary embolism diagnosis. Breathe (Sheff). 2024; 20(1):230228. doi: 10.1183/20734735.0228-2023 EDN: LNAYLM</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Viteri-Ramírez G, García-Lallana A, Simón-Yarza I, et al. Low radiation and low-contrast dose pulmonary CT angiography: comparison of 80 kVp/60 ml and 100 kVp/80 ml protocols. Clinical Radiology. 2012;67(9):833–839. doi: 10.1016/j.crad.2011.11.016</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Gietema HA, Walraven KHM, Posthuma R, et al. Dual-energy computed tomography compared to lung perfusion scintigraphy to assess pulmonary perfusion in patients screened for endoscopic lung volume reduction. Respiration. 2021;100(12):1186–1195. doi: 10.1159/000517598 EDN: HCPPYM</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Im DJ, Hur J, Han K, et al. Prognostic value of dual-energy CT-based iodine quantification versus conventional CT in acute pulmonary embolism: a propensity-match analysis. Korean Journal of Radiology. 2020;21(9):1095. doi: 10.3348/kjr.2019.0645 EDN: ZLWQQL</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Zhang LJ, Zhou CHSH, Schoepf UJ, et al. Dual-energy CT lung ventilation/perfusion imaging for diagnosing pulmonary embolism. European Radiology. 2013;23(10):2666–2675. doi: 10.1007/s00330-013-2907-x EDN: HTDZSY</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Yang GF, Yang X, Zhang LJ, et al. Pulmonary enhancement imaging with dual energy CT for the detection of pulmonary embolism in a rabbit model. Academic Radiology. 2011;18(5):605–614. doi: 10.1016/j.acra.2010.12.012</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Nikolaou K, Tiem S, Sommer W, et al. Diagnosing pulmonary embolism: new computed tomography applications. Journal of Thoracic Imaging. 2010;25(2):151–160. doi: 10.1097/RTI.0b013e3181d9ca1d</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Zhang LJ, Wang ZJ, Zhou CS, et al. Evaluation of pulmonary embolism in pediatric patients with nephrotic syndrome with dual energy CT pulmonary angiography. Academic Radiology. 2012;19(3):341–348. doi: 10.1016/j.acra.2011.11.002</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Ruggiero A, Screaton NJ. Imaging of acute and chronic thromboembolic disease: state of the art. Clinical Radiology. 2017;72(5):375–388. doi: 10.1016/j.crad.2017.02.011</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Otrakji A, Digumarthy SR, Lo Gullo R, et al. Dual-energy CT: spectrum of thoracic abnormalities. RadioGraphics. 2016;36(1):38–52. doi: 10.1148/rg.2016150081</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Rassouli N, Etesami M, Dhanantwari A, Rajiah P. Detector-based spectral CT with a novel dual-layer technology: principles and applications. Insights into Imaging. 2017;8(6):589–598. doi: 10.1007/s13244-017-0571-4 EDN: RIGZBG</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Ermolaev VL, Stolin AV, Shurygina EP, et al. Capabilities of traditional integrated approach to diagnosis and management of acute pulmonary embolism. Ural Medical Journal. 2010;7(72):58–62. EDN: MWJYVB</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Zabavskaya OA, Sharifullin FA, Kokov LS. Capabilities of multispiral computer tomography in differential diagnosis of pulmonary embolism. In: Proceedings of the scientific and practical conference «New technologies in emergency and urgent medical care». Suzdal, 2016 Apr 21–22. Moscow: N.V. Sklifosovsky Research Institute of Emergency Care. P. 131–132. (In Russ.)</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Perrier A, Howarth N, Didier D, et al. Performance of helical computed tomography in unselected outpatients with suspected pulmonary embolism. Annals of Internal Medicine. 2001;135(2):88. doi: 10.7326/0003-4819-135-2-200107170-00008</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Van Strijen MJ, De Monye W, Kieft GJ, et al. Accuracy of single-detector spiral CT in the diagnosis of pulmonary embolism: a prospective multicenter cohort study of consecutive patients with abnormal perfusion scintigraphy. Journal of Thrombosis and Haemostasis. 2005;3(1):17–25. Corrected and republished from: Journal of Thrombosis and Haemostasis. 2005;3(3):622. doi: 10.1111/j.1538-7836.2004.01064.x</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Mullins MD, Becker DM, Hagspiel KD, Philbrick JT. The role of spiral volumetric computed tomography in the diagnosis of pulmonary embolism. Archives of Internal Medicine. 2000;160(3):293–298. doi: 10.1001/archinte.160.3.293</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Prokop M, Galanski M, editors. Spiral and multislice computer tomography of the body. New York: Thieme; 2003.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Kelly AM. Imaging in thromboembolic disease. Imaging Med. 2011;3(1):31–50.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Gottschalk A, Sostman HD, Coleman RE, et al. Ventilation-perfusion scintigraphy in the PIOPED study. Part II. Evaluation of the scintigraphic criteria and interpretations. J Nucl Med. 1993;34(7):1119–1126.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Waterstram-Rich KM, Gilmore D. Respiratory system. In: Gilmore D, Waterstram-Rich KM. Nuclear Medicine and PET/CT: technology and techniques. 8th ed. St. Louis, MO: Mosby Elsevier; 2016. P. 475–487.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Chan K, Ioannidis S, Coghlan JG, et al. Pulmonary arterial hypertension with abnormal V/Q single-photon emission computed tomography. JACC: Cardiovascular Imaging. 2018;11(10):1487–1493. doi: 10.1016/j.jcmg.2017.07.026 EDN: RDHSTD</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Yu L, Leng S, McCollough CH. Dual-energy CT–based monochromatic imaging. American Journal of Roentgenology. 2012;199(suppl. 5):S9–S15. doi: 10.2214/AJR.12.9121</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Lenga L, Trapp F, Albrecht MH, et al. Single- and dual-energy CT pulmonary angiography using second- and third-generation dual-source CT systems: comparison of radiation dose and image quality. European Radiology. 2019;29(9):4603–4612. doi: 10.1007/s00330-018-5982-1 EDN: YGLIHW</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Weidman EK, Plodkowski AJ, Halpenny DF, et al. Dual-energy CT angiography for detection of pulmonary emboli: incremental benefit of iodine maps. Radiology. 2018;289(2):546–553. doi: 10.1148/radiol.2018180594</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Masy M, Giordano J, Remy J, et al. Dual-energy CT (DECT) lung perfusion in pulmonary hypertension: concordance rate with V/Q scintigraphy in diagnosing chronic thromboembolic pulmonary hypertension (CTEPH). European Radiology. 2018;28(12):5100–5110. doi: 10.1007/s00330-018-5467-2 EDN: HBNJYG</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Takx RAP, Henzler T, Schoepf UJ, et al. Predictive value of perfusion defects on dual energy CTA in the absence of thromboembolic clots. Journal of Cardiovascular Computed Tomography. 2017;11(3):183–187. doi: 10.1016/j.jcct.2017.04.005</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Mershina EA, Sinitsyn VE, Plotnikova ML,et al. Use of dual-energy computed tomographic angiopulmonography in patients with chronic thromboembolic pulmonary hypertension before and after pulmonary artery thromboendarterectomy. Journal of Radiology and Nuclear Medicine. 2013;2:27–31. EDN: RGQWTT</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Ohno Y, Ozawa Y, Nagata H, et al. Area-detector computed tomography for pulmonary functional imaging. Diagnostics. 2023;13(15):2518. doi: 10.3390/diagnostics13152518 EDN: LXLBNJ</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Hong YJ, Shim J, Im DJ, et al. Dual-energy CT for pulmonary embolism: current and evolving clinical applications. Korean Journal of Radiology. 2021;22(9):1555–1568. doi: 10.3348/KJR.2020.1512 EDN: EFSHLY</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Tamura M, Yamada Y, Kawakami T, et al. Diagnostic accuracy of lung subtraction iodine mapping CT for the evaluation of pulmonary perfusion in patients with chronic thromboembolic pulmonary hypertension: correlation with perfusion SPECT/CT. International Journal of Cardiology. 2017;243:538–543. doi: 10.1016/j.ijcard.2017.05.006</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Shahin Y, Johns C, Karunasaagarar K, et al. IodiNe subtraction mapping in the diagnosis of pulmonary chronIc thRomboEmbolic disease (INSPIRE): rationale and methodology of a cross-sectional observational diagnostic study. Contemporary Clinical Trials Communications. 2019;15:100417. doi: 10.1016/j.conctc.2019.100417</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Tsuchiya N, van Beek EJR, Ohno Y, et al. Magnetic resonance angiography for the primary diagnosis of pulmonary embolism: a review from the international workshop for pulmonary functional imaging. World Journal of Radiology. 2018;10(6):52–64. doi: 10.4329/wjr.v10.i6.52</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Fu Q, Cheng Q, Kong X, et al. Diagnostic accuracy of true fast imaging with steady-state precession, MR pulmonary angiography and volume-interpolated body examination for pulmonary embolism compared with CT pulmonary angiography. Experimental and Therapeutic Medicine. 2020;21(1):42. doi: 10.3892/etm.2020.9474 EDN: VLQMDT</mixed-citation></ref></ref-list></back></article>
