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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Digital Diagnostics</journal-id><journal-title-group><journal-title xml:lang="en">Digital Diagnostics</journal-title><trans-title-group xml:lang="ru"><trans-title>Digital Diagnostics</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Digital Diagnostics</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2712-8490</issn><issn publication-format="electronic">2712-8962</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">697955</article-id><article-id pub-id-type="doi">10.17816/DD697955</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Научные обзоры</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="zh"><subject>科学评论</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Neural Network Analysis of Non-Neoplastic Liver Histology</article-title><trans-title-group xml:lang="ru"><trans-title>Нейросетевой анализ гистологии при неопухолевых поражениях печени</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title/></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1686-5629</contrib-id><name-alternatives><name xml:lang="en"><surname>Novikova</surname><given-names>Tatiana</given-names></name><name xml:lang="ru"><surname>Новикова</surname><given-names>Татьяна Олеговна</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>Врач-патологоанатом</p></bio><email>tn.path1910@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Melikbekyan</surname><given-names>Ashot Arsenovich</given-names></name><name xml:lang="ru"><surname>Меликбекян</surname><given-names>Ашот Арсенович</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><email>melikbekyan.ashot@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9699-8375</contrib-id><contrib-id contrib-id-type="spin">8948-9169</contrib-id><name-alternatives><name xml:lang="en"><surname>Borbat</surname><given-names>Artyom M.</given-names></name><name xml:lang="ru"><surname>Борбат</surname><given-names>Артём Михайлович</given-names></name><name xml:lang="zh"><surname>Borbat</surname><given-names>Artyom M.</given-names></name></name-alternatives><address><country country="DE">Germany</country></address><email>aborbat@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">LLC Laboratoires De Genie, Moscow, Russia</institution></aff><aff><institution xml:lang="ru">"ООО "Лаборатуар Де Жени", Москва, Россия</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff id="aff2"><institution></institution></aff><aff id="aff3"><institution>MVZ Pathologie Spandau</institution></aff><pub-date date-type="preprint" iso-8601-date="2026-05-20" publication-format="electronic"><day>20</day><month>05</month><year>2026</year></pub-date><volume>7</volume><issue>2</issue><issue-title xml:lang="ru"/><history><date date-type="received" iso-8601-date="2025-12-08"><day>08</day><month>12</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2026-04-23"><day>23</day><month>04</month><year>2026</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; , Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; , Эко-вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; , Eco-Vector</copyright-statement><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-вектор</copyright-holder><copyright-holder xml:lang="zh">Eco-Vector</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://jdigitaldiagnostics.com/DD/article/view/697955">https://jdigitaldiagnostics.com/DD/article/view/697955</self-uri><abstract xml:lang="en"><p>This review explores the application of neural network models to the analysis of histological images in non-neoplastic liver diseases. It covers available datasets, model architectures, training strategies, and loss functions. While the potential of such approaches is high, their adoption is limited by the scarcity of annotated data, reliance on general-purpose architectures, labor-intensive annotation processes, and infrequent use of multimodal integration. Particular attention is given to preprocessing methods, data augmentation, and the prospects of weakly supervised learning. The review highlights the need for specialized architectures and standardized strategies for incorporating contextual information. It emphasizes the importance of advancing technical solutions that address liver-specific morphological patterns and diagnostic challenges beyond oncopathology.</p></abstract><trans-abstract xml:lang="ru"><p>Обзор посвящён применению нейросетевых моделей для анализа гистологических изображений при неопухолевых заболеваниях печени. Рассмотрены доступные датасеты, архитектуры моделей, стратегии обучения и используемые функции потерь. Показано, что несмотря на высокий потенциал таких решений, их внедрение сдерживается ограниченностью размеченных данных, преобладанием универсальных архитектур, высокой трудоёмкостью аннотирования и редким использованием многомодальных подходов. Особое внимание уделено методам предобработки изображений, аугментации, а также перспективам использования weakly supervised learning. Отмечена необходимость в специализированных архитектурах и стандартизированных методах интеграции контекстной информации. Работа подчёркивает значимость развития технических решений, учитывающих морфологические особенности печени и диагностические задачи за пределами онкопатологии.</p></trans-abstract><trans-abstract xml:lang="zh"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>non-neoplastic liver lesions, hepatocytes, artificial intelligence, neural network models, image preprocessing methods, loss functions</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>неопухолевые поражения печени, гепатоциты, искусственный интеллект, нейросетевые модели, методы предобработки изображений, функции потерь</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Ivashkin VT, Maevskaya MV, Zharkova MS, et al. 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