Microarray analysis of peripheral blood lymphocytes transcriptome in breast cancer patients

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Breast cancer is number one in terms of indicators of mortality and morbidity in women. In postgenomicera it was revealed that pathology development is linked with specificities of gene expression including transcriptional, posttransctiptional, translational, epigenetical regulation. In research was included biomaterial of 16 patients (8 patients with I/ IIstage luminal A breast cancer and 8 healthy women). Functional enrichment analysis using WebGestalt source and different databases (Gene Ontology, KEGG) showed alterations in expression of genes involved in immunological response, metabolism of carbohydrates, glutathione and nicotinamide, DNA repair, ion transport and intracellular signals transition. Obtained results expand our vision about specificities of blood mononuclears transcriptome during breast cancer on early stage.

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Sobre autores

V. Minina

Federal Research Centre of Coal and Coal Chemistry, Siberian Branch of the Russian Academy of Sciences; Kemerovo State University

Email: vladislasbus2358@yandex.ru
Rússia, Kemerovo, 650000; Kemerovo, 650000

R. Titov

Federal Research Centre of Coal and Coal Chemistry, Siberian Branch of the Russian Academy of Sciences; Kemerovo State University

Email: vladislasbus2358@yandex.ru
Rússia, Kemerovo, 650000; Kemerovo, 650000

V. Buslaev

Federal Research Centre of Coal and Coal Chemistry, Siberian Branch of the Russian Academy of Sciences

Autor responsável pela correspondência
Email: vladislasbus2358@yandex.ru
Rússia, Kemerovo, 650000

R. Savchenko

Tomsk National Research Medical Centre, Russian Academy of Sciences

Email: vladislasbus2358@yandex.ru

Scientific Research Institute of Medical Genetics

Rússia, Tomsk, 634050

A. Slepcov

Tomsk National Research Medical Centre, Russian Academy of Sciences

Email: vladislasbus2358@yandex.ru

Scientific Research Institute of Medical Genetics

Rússia, Tomsk, 634050

M. Bakanova

Federal Research Centre of Coal and Coal Chemistry, Siberian Branch of the Russian Academy of Sciences; Kemerovo State Medical University

Email: vladislasbus2358@yandex.ru
Rússia, Kemerovo, 650000; Kemerovo, 650000

N. Gavrineva

Kemerovo State University

Email: vladislasbus2358@yandex.ru
Rússia, Kemerovo, 650000

M. Katanakhova

Federal Research Centre of Coal and Coal Chemistry, Siberian Branch of the Russian Academy of Sciences

Email: vladislasbus2358@yandex.ru
Rússia, Kemerovo, 650000

A. Glushkov

Federal Research Centre of Coal and Coal Chemistry, Siberian Branch of the Russian Academy of Sciences

Email: vladislasbus2358@yandex.ru
Rússia, Kemerovo, 650000

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2. Fig. 1. Protein network for overexpressed genes based on the TCGARefseq (BRCA) database.

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3. Fig. 2. Protein network for downregulated genes based on the TCGARefseq (BRCA) database.

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