Contemporary perceptions about mechanisms of harmful impacts exerted by N-nitrosamines on human health and specific markers of pathological effects initiated by them (analytical review)

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Abstract

Nitrosamines have toxic properties with a wide range of biological effects including mutagenic, carcinogenic, embryotoxic, teratogenic ones as well as effects on specific target organs or systems. Technogenic transformations result in greater emissions of nitrogen-containing chemicals into ambient air. This leads to their subsequent accumulation in the environment and human body and initialization of nitrosation involving occurrence of highly toxic N-nitrosamines (NA). Levels of nitrites/nitrates and NA in foods and drinking water, which are higher than established safety standards, and elevated endogenous NA formation induce various pathological processes in the human body including oncological ones. Identification of the most promising trends in preventive sanitary-hygienic activities and medical and preventive technologies requires generalization of accumulated sanitary-hygienic, epidemiological, and clinical and laboratory data.

The aim of this study was to generalize contemporary perceptions about mechanisms of harmful impacts exerted by NA on human health and the most effective methods for identifying pathological processes initiated by them. Literature analysis relied on reviewing databases belonging to electronic scientific libraries including CyberLeninka and eLIBRARY.RU, the United States National Library of Medicine, Central Scientific Medical Library, Rukont National Digital Resource over the last 15 years. The review covers data on NA sources and ways of entering the human body; the most effective techniques for their identification; safe NA levels in food products and medications; mechanisms of harmful impacts and initiated pathological processes; as well as markers of exposure and effect. The most effective techniques for NA identification include HPLC and GC with MS — MS. Markers of NA occurrence in environmental objects include NDMA, NMEA, NDEA, NPR, NDPA, NPIP, NDBA; markers of exposure, NDMA, NDEA, NNK and NNN in biological media; markers of the effect include indicators of oxidative stress, levels of pro-inflammatory and anti-inflammatory cytokines, stress-hormones, lipid profile indicators, indicators of immune suppression and apoptotic activity, IgG specific to NA and tumor markers for CEA and CA 19-9.

Contribuition:
Ustinova O.Yu. — concept and design of the study, collection of material, writing and editing the text;
Leshkova I.V. — collecting material, writing and editing text;
Vlasova E.M. — collecting material, writing, and editing text;
Vorobyova A.A. — collecting material, writing, and editing text.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: February 16, 2024 / Accepted: April 9, 2024 / Published: June 17, 2024

 

About the authors

Olga Yu. Ustinova

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies of the Federal Service for Surveillance over Consumer Rights Protection and Human Wellbeing; Perm State Scientific Research University,

Author for correspondence.
Email: ustinova@fcrisk.ru
ORCID iD: 0000-0002-9916-5491

MD, PhD, DSci., Professor, Deputy Director for Healthcare Services at the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, 614045, Russian Federation; Professor at the Microbiology and Immunology Department of the Biology Faculty, Perm State Scientific Research University, Perm, 614068, Russian Federation

e-mail: ustinova@fcrisk.ru

Russian Federation

Irina V. Leshkova

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies of the Federal Service for Surveillance over Consumer Rights Protection and Human Wellbeing

Email: noemail@neicon.ru
ORCID iD: 0000-0002-6161-8897

Physician at the sanatorium of the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, 614045, Russian Federation

Russian Federation

Elena M. Vlasova

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies of the Federal Service for Surveillance over Consumer Rights Protection and Human Wellbeing

Email: vlasovaem@fcrisk.ru
ORCID iD: 0000-0003-3344-3361

MD, PhD, Head of the Occupational Pathology Center (occupational pathologist) of the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, 614045, Russian Federation

e-mail: vlasovaem@fcrisk.ru

Russian Federation

Alena A. Vorobyeva

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies of the Federal Service for Surveillance over Consumer Rights Protection and Human Wellbeing

Email: epletina-alena@rambler.ru
ORCID iD: 0000-0002-8747-8773

MD, PhD, Head of the sanatorium of the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, 614045, Russian Federation

e-mail: epletina-alena@rambler.ru

Russian Federation

References

  1. Actual Problems of Population Health Management: Collection of Scientific Papers of the IV All-Russian Scientific and Practical Conference. Issue XIV. Volume 2. [Aktual’nye problemy upravleniya zdorov’em naseleniya: Sbornik nauchnykh trudov IV Vserossiiskoi nauchno-prakticheskoi konferentsii. Vypusk XIV. Tom 2]. Nizhnii Novgorod; 2021. (in Russian)
  2. Shepel’ D. The content of N-nitrosamines in environmental objects. In: Science in the North of the Republic of Moldova: Achievements, Problems, Prospects [Nauka na severe Respubliki Moldova: dostizheniya, problemy, perspektivy]. Bel’tsy: Tsentral’naya Tipografiya; 2021: 195–200. (in Russian)
  3. Etemadi A., Sinha R., Ward M.H., Graubard B.I., Inoue-Choi M., Dawsey S.M., et al. Mortality from different causes associated with meat, heme iron, nitrates, and nitrites in the NIH-AARP Diet and Health Study: population based cohort study. BMJ. 2017; 357: j1957. https://doi.org/10.1136/bmj.j1957
  4. Tociu C., Marcu E., Ciobotaru I.E., Maria C. Risk assessment of population exposure to nitrates/nitrites in groundwater: a case study approach ECTOTERRA. J. Env. Prot. 2016; 13(3): 3945.
  5. Zaitseva N.V., Ulanova T.S., Nurislamova T.V., Popova N.A., Mal’tseva O.A. Quantitative parameters of nitrates in urine and N-nitrosodimethylamine in blood as markers of the oral exposure to nitrates introduced with drinking water. Gigiena i Sanitaria (Hygiene and Sanitation, Russian journal). 2018; 97(11): 1087–92. https://doi.org/10.18821/0016-9900-2018-97-11-1087-92 https://elibrary.ru/ypxhxn (in Russian)
  6. Mal’tseva O.A. Methodological and criteria support for biomedical monitoring of nitrates and N-nitrosoamines in drinking water and human biological media: abstract of the dissertation of the candidate biological sciences: Diss. Moscow; 2018. (in Russian)
  7. Osipenko B.G., Portyanaya N.I., Polyakova L.O., Novokhatskii N.K. Dimetylnitrosamine – hepatotropic poison and cancerogene - indices of biochemical blood systems in acute poisoning. Baikal’skii meditsinskii zhurnal. 2005; 57(7): 17–21. https://elibrary.ru/jrgyoj (in Russian)
  8. Galachiev S.M., Makoeva L.M., Dzhioev F.K., Gurina A.E., Kozhieva I.S., Bolieva M.B. Environmental pollution is the main reason for the formation of nitrosamines with carcinogenic properties. Vestnik MANEB. 2022; 27(4): 112–6. https://elibrary.ru/kbhrda (in Russian)
  9. Ocheret N.P., Tuguz F.V. Content of nitrates in foodstuff and their influence on health of the person. Vestnik Adygeiskogo gosudarstvennogo universiteta. Seriya: Estestvenno-matematicheskie i tekhnicheskie nauki. 2018; (2): 86–92. https://elibrary.ru/zujwsc (in Russian)
  10. Abdurazakova Kh.N., Gitinova P.Sh., Abakarova A.M. The modern state of the problem potential mutagenic and carcinogenic activity of food products. Sanitarnyi vrach. 2021; (10): 25–36. https://doi.org/10.33920/med-08-2110-02 https://elibrary.ru/amwihs (in Russian)
  11. Okhotina N.A., Sharipov E.N., Il’yazov M.F. Problems of contamination of rubber industry products with polycyclic aromatic hydrocarbons. Part 1. Vestnik Kazanskogo tekhnologicheskogo universiteta. 2013; 16(3): 129–31. https://elibrary.ru/pvvdpj (in Russian)
  12. Rudneva I.I., Omel’chenko S.O. Nitrosamines in aquatic ecosystems: sources, formation, toxicity, environmental risk (Review) 1. Structure, properties, ways of entering and formation in waterbodies. Vodnye resursy. 2021; 48(1): 80–9. https://doi.org/10.1134/S0097807821010255 https://elibrary.ru/vximtw (in Russian)
  13. Sigora G.A., Khomenko T.Yu., Lyashko T.V., Nichkova L.A. The problem of the study of the ecological condition of springs of the Sevastopol region. Ekonomika stroitel’stva i prirodopol’zovaniya. 2019; (1): 115–23. https://elibrary.ru/zyyuwl (in Russian)
  14. Park S.J., Jeong M.J., Park S.R., Choi J.C., Choi H., Kim M. Release of N-nitrosamines and N-nitrosatable substances from baby bottle teats and rubber kitchen tools in Korea. Food Sci. Biotechnol. 2018; 27(5): 1519–24. https://doi.org/10.1007/s10068-018-0373-6
  15. Hwang J.B., Lee J.E., Kim E., Eom K.Y., Kim H.A., Lee S. Analysis of N-nitrosamines and N-nitrosatable substances from baby bottle rubber teats by liquid chromatography tandem mass spectrometry. Food Addit. Contam. Part A Chem. Anal. Control. Expo. Risk Assess. 2023; 40(4): 518–27. https://doi.org/10.1080/19440049.2023.2193276
  16. Khorol’skii M.D., Vlasov A.M. Determination of the content of nitrosamines in medicines valsartan, losartan and irbesartan in circulation in the Russian Federation. Vestnik sovremennykh issledovanii. 2020; (8–1): 64–9. https://elibrary.ru/dluvwx (in Russian)
  17. Parr M.K., Joseph J.F. NDMA impurity in valsartan and other pharmaceutical products: Analytical methods for the determination of N-nitrosamines. J. Pharm. Biomed. Anal. 2019; 164: 536–49. https://doi.org/10.1016/j.jpba.2018.11.010
  18. Shchetinin P.P., Senchenko S.P., Gordeev K.K. N-nitrosamine impurities in medicines: toxicity, formation pathways, methods of determination, and limits (review). Razrabotka i registratsiya lekarstvennykh sredstv. 2020; 9(4): 180–90. https://doi.org/10.33380/2305-2066-2020-9-4-180-190 https://elibrary.ru/rjjygh (in Russian)
  19. Schrenk D., Bignami M., Bodin L., Chipman J.K., Del Mazo J., Hogstrand C., et al. Risk assessment of N-nitrosamines in food. EFSA J. 2023; 21(3): e07884. https://doi.org/10.2903/j.efsa.2023.7884
  20. Tutelyan V.A., Nikityuk D.B., eds. Appendix to the National Guidelines «Nutritionology and Clinical Dietetics» [Prilozhenie k natsional’nomu rukovodstvu «Nutritsiologiya i klinicheskaya dietologiya»]. Moscow: GEOTAR-Media; 2020. (in Russian)
  21. Korotova D.M. Biological Safety of Food Systems: A Short Course of Lectures for Students of the IV Year of Training 19.03.03 – «Food of animal origin» Training Profile «Technology of milk and dairy products» [Biologicheskaya bezopasnost’ pishchevykh sistem: kratkii kurs lektsii dlya studentov IV kursa napravleniya podgotovki 19.03.03 – «Produkty pitaniya zhivotnogo proiskhozhdeniya» profil’ podgotovki «Tekhnologiya moloka i molochnykh produktov»]. Saratov; 2015. (in Russian)
  22. Fokin V.A., Zelenkin S.E. The list of priority chemicals for development of food contaminants’ hygienic standards according to health risk criteria. Zdorov’e naseleniya i sreda obitaniya – ZNiSO. 2017; 25(10): 39–42. https://doi.org/10.35627/2219-5238/2017-295-10-39-42 https://elibrary.ru/zruvpb (in Russian)
  23. Vdovkina M.A. Metabolism of N-nitrosamines in the body of cattle: Diss. Moscow; 2001. (in Russian)
  24. Lakiza N.V., Neudachina L.K. Food Analysis [Analiz pishchevykh produktov]. Ekaterinburg; 2015. (in Russian)
  25. Saldan I.P., Shved O.I., Balandovich B.A., Nagornyak A.S., Mazko O.N., Makarova O.G., et al. Assessment of risks caused by impacts exerted on a human body by nitrates contained in food products. Analiz riska zdorov’yu. 2018; (4): 81–8. https://doi.org/10.21668/health.risk/2018.4.09.eng https://elibrary.ru/codzkv
  26. Galachiev S.M., Makoeva L.M., Dzhioev F.K., Khaeva L.Kh. Possibilities of nitrosamines endogenous formation in gastric juice in vitro. Izvestiya Samarskogo nauchnogo tsentra RAN. 2011; 13(1-7): 8–11. https://elibrary.ru/plvstp (in Russian)
  27. EFSA Panel on Contaminants in the Food Chain (EFSA CONTAM Panel). Risk assessment of N-nitrosamines in food. EFSA J. 2023; 21(3): e07884. https://doi.org/10.2903/j.efsa.2023.7884
  28. Control of Nitrosamine Impurities in Human Drugs. Guidance for Industry. Available at: https://fda.gov/media/141720/download
  29. Shaglaeva Z.S. Nitrates and their effects on the human body. In: Modern Science: Current Issues, Achievements and Innovations Collection of Articles of the VII International Scientific and Practical Conference. Part 1 [Sovremennaya nauka: aktual’nye voprosy, dostizheniya i innovatsii sbornik statei VII Mezhdunarodnoi nauchno-prakticheskoi konferentsii. Chast’ 1]. Penza; 2019: 72–4. (in Russian)
  30. Chernichenko I.A., Shvager O.V., Litvichenko O.N., Sovertkova L.S. Effective introduction of environmental health risk assessment methodology at the regional level. Zdorov’e i okruzhayushchaya sreda. 2015; (25–1): 102–6. https://elibrary.ru/zaugzd (in Russian)
  31. Taneja P., Labhasetwar P., Nagarnaik P., Ensink J.H.J. The risk of cancer as a result of elevated levels of nitrate in drinking water and vegetables in Central India. J. Water Health. 2017; 15(4): 602–14. https://doi.org/10.2166/wh.2017.283
  32. Li H., Jönsson B.A., Lindh C.H., Albin M., Broberg K. N-nitrosamines are associated with shorter telomere length. Scand J. Work Environ. Health. 2011; 37(4): 316–24. https://doi.org/10.5271/sjweh.3150
  33. Manskikh V.N. Impact of chemical carcinogens on amphibia. Voprosy onkologii. 2006; 52(1): 25–31. https://elibrary.ru/kvwpnn (in Russian)
  34. Kel’makov V.V., Trofimovich E.M., Stupak E.V., Simanovich A.E., Stupak V.V. Environmental factors and morbidity of the population with primary tumors of the central nervous system. Sovremennye problemy nauki i obrazovaniya. 2022; (6–2): 33–45. https://doi.org/10.17513/spno.32287 https://elibrary.ru/ntvebc (in Russian)
  35. Zyablov E.V., Chesnokova N.P., Barsukov V.Yu. Thyroid cancer: modern concepts of etiology and pathogenesis. Nauchnoe obozrenie. Meditsinskie nauki. 2016; (3): 37–61. https://elibrary.ru/wlxieb (in Russian)
  36. Denishev R.R., Chirin A.S. Modern ideas about the factors of gastric cancer development, the formation of risk groups for this oncopathology. Byulleten’ meditsinskikh internet-konferentsii. 2016; 6(5): 1043. (in Russin)
  37. Pryanichnikova M.B. Modern hypotheses of development of bladder cancer. Urologiya. 2014; (1): 88–91. https://elibrary.ru/ryhwez (in Russian)
  38. Galachiev S.M., Makoeva L.M., Dzhioev F.K., Gurina A.E., Khaeva L.Kh. Endogenous formation of nitrosamines in gastric juice is a consequence of man–made human activity. Vestnik MANEB. 2018; 23(4): 74–7. https://elibrary.ru/yxpirv (in Russian)
  39. Balenko N.V., Sovertkova L.S., Litvichenko O.M., Nikitina N.G. Assessment of the genotoxic danger of the combined action of endogenous nitrosamines and the magnetic field of industrial frequency (50 Hz) by the micronuclear method. In: Health and the Environment. Collection of Materials of the Republican Scientific and Practical Conference with International Participation Dedicated to the 90th Anniversary of the Republican Unitary Enterprise «Scientific and Practical Center of Hygiene»: in 2 volumes. Volume 1 [Zdorov’e i okruzhayushchaya sreda. Sbornik materialov respublikanskoi nauchno-prakticheskoi konferentsii s mezhdunarodnym uchastiem, posvyashchennoi 90-letiyu respublikanskogo unitarnogo predpriyatiya “Nauchno-prakticheskii tsentr gigieny”: v 2-kh tomakh. Tom 1]. 2017; 7–9. https://elibrary.ru/nsgbal (in Russian)
  40. Galloway S.M. International regulatory requirements for genotoxicity testing for pharmaceuticals used in human medicine, and their impurities and metabolites. Environ. Mol. Mutagen. 2017; 58(5): 296–324. https://doi.org/10.1002/em.22077
  41. Khorokhol’skii M.D. Development and validation of methods for determining impurities with potential genotoxicity in the standardization of pharmaceutical substances: Diss. Moscow; 2021. (in Russian)
  42. Rais R.Kh., Gulyaeva L.F. Biological Effects of Toxic Compounds: A Course of Lectures [Biologicheskie effekty toksicheskikh soedinenii: kurs lektsii]. Novosibirsk; 2003. https://elibrary.ru/qknucx (in Russian)
  43. Yarovataya M.A., Takanaev A.A., Yushkova E.I. Metabolism of heterociclic Nnitrosamines. Uchenye zapiski Orlovskogo gosudarstvennogo universiteta. Seriya: Estestvennye, tekhnicheskie i meditsinskie nauki. 2015; (4): 424–5. https://elibrary.ru/uzdgtb (in Russian)
  44. Dolgina N.A., Fedorenko E.V., Dudchik N.V., Emel’yanova O.A., Il”yukova I.I., Anisovich M.V. Estimation of the genotoxic potential of a number of polyaromatic hydrocarbons and Nitrozamines in a battery of tests. Zdorov’e i okruzhayushchaya sreda. 2019; (29): 114–9. https://elibrary.ru/cjogak (in Russian)
  45. Takanaev A.A., Khalilov M.A., Yushkova E.I., Yarovataya M.A. Some aspects of Nnitrosocompounds` biotransformation. Uchenye zapiski Orlovskogo gosudarstvennogo universiteta. Seriya: Estestvennye, tekhnicheskie i meditsinskie nauki. 2015; (4): 404–6. https://elibrary.ru/uzdgqt (in Russian)
  46. Rumyantsev A.Sh., Lyndina M.L., Shishkin A.N. Smoking and kidneys. Nefrologiya. 2018; 22(1): 9–28. https://doi.org/10.24884/1561-6274-2018-22-1-9-28 https://elibrary.ru/yqalmr (in Russian)
  47. Salahshoor M.R., Azari P., Roshankhah S., Zokaei A., Foroughinia A. The effect of Crocin on sperm parameters disorders induced by peripheral administration of nitrosamines in male rats. J. Med. Life. 2022; 15(3): 362–7. https://doi.org/10.25122/jml-2019-0144
  48. Sheweita S.A., El Banna Y.Y., Balbaa M., Abdullah I.A., Hassan H.E. N-nitrosamines induced infertility and hepatotoxicity in male rabbits. Environ. Toxicol. 2017; 32(9): 2212–20. https://doi.org/10.1002/tox.22436
  49. Lovinskaya A.V., Kolumbaeva S.Zh., Kolomiets O.L., Abilev S.K. Genotoxic effects of N-nitrosodimethylamine in somatic and generative cells of mice. Ekologicheskaya genetika. 2017; 15(3): 34–41. https://doi.org/10.17816/ecogen15334-41 https://elibrary.ru/zmzgab (in Russian)
  50. Luo Q., Miao Y., Liu C., Bei E., Zhang J.F., Zhang L.H., et al. Maternal exposure to nitrosamines in drinking water during pregnancy and birth outcomes in a Chinese cohort. Chemosphere. 2023; 315: 137776. https://doi.org/10.1016/j.chemosphere.2023.137776
  51. Zhang H., Zhao C., Liu Q., Zhang Y., Luo K., Pu Y., et al. Dysregulation of fatty acid metabolism associated with esophageal inflammation of ICR mice induced by nitrosamines exposure. Environ. Pollut. 2022; 297: 118680. https://doi.org/10.1016/j.envpol.2021.118680
  52. George J., Tsuchishima M., Tsutsumi M. Molecular mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic fibrosis. Cell Death Dis. 2019; 10(1): 18. https://doi.org/10.1038/s41419-018-1272-8
  53. Zhang H., Lu L., Zhao C., Liu Q., Zhou Q., Zhang Y., et al. Lipid metabolism disorders contribute to hepatotoxicity of ICR mice induced by nitrosamines exposure. Environ. Int. 2022; 167: 107423. https://doi.org/10.1016/j.envint.2022.107423
  54. Nuruev E.A. The effect of N-nitrosamines on rat liver cells. In: Current Problems and Achievements in Medicine: Collection of Scientific Papers on the Results of the International Scientific and Practical Conference. Issue IV [Aktual’nye problemy i dostizheniya v meditsine: sbornik nauchnykh trudov po itogam mezhdunarodnoi nauchno-prakticheskoi konferentsii. Vypusk IV]. Samara; 2017: 28–9. https://elibrary.ru/ynqgup (in Russian)
  55. Zhigacheva I.V., Burlakova E.B., Evseenko L.S., Kaplan E.Ya., Krivosheeva L.V., Bulanova E.G., et al. Humoral immunity: polycyclic aromatic hydrocarbons and nitrosamines. Doklady akademii nauk. 2002; 383(6): 120–2. https://elibrary.ru/lhaadd
  56. Landrigan P.J. Children’s environmental health: a brief history. Acad. Pediatr. 2016; 16(1): 1–9. https://doi.org/10.1016/j.acap.2015.10.002
  57. Maklakova O.A., Valina S.L., Shtina I.E., Ustinova O.Yu. Assessing risks of hepatobiliary disorders in children under combined exposure to persisting herpes and technogenic chemicals. Analiz riska zdorov’yu. 2023; (3): 76–82. https://doi.org/10.21668/health.risk/2023.3.07 https://elibrary.ru/wbehne (in Russian)
  58. Malyutina N.N., Taranenko L.A. Pathophysiological and clinical aspects of exposure to methanol and formaldehyde on human body. Sovremennye problemy nauki i obrazovaniya. 2014; (2): 367–9. https://elibrary.ru/sbwhsn (in Russian)
  59. Enikeev D.A., Idrisova L.T., Enikeev O.A., Kuznetsov K.O., Akhmadeeva D.R., Enikeeva S.A., et al. Comparison of hazard and toxicity of tobacco cigarettes, electronic nicotine delivery systems, and tobacco heating systems (IQOS) (review). Patogenez. 2019; 17(3): 25–33. https://elibrary.ru/ixjpfu (in Russian)
  60. Dolgikh O.V. Markers of sensitization in children under conditions of high nitrate content in drinking water. Allergologiya i immunologiya. 2016; 17(2): 144–5. (in Russian)
  61. Grigorenko L.E., Spasskaya Yu.S., Moldavskaya N.B., Balenko N.V., Sovertkova L.S. Indicators of congenital nonspecific immunity experimental animals are exposed to precursors of cancirogenic nitrosamines within 3 months. Zdorov’e i okruzhayushchaya sreda. 2015; (25–2): 92–6. https://elibrary.ru/zauhwp (in Russian)
  62. Iwaniuk A., Grubczak K., Ratajczak-Wrona W., Garley M., Nowak K., Jabłońska E. N-nitrosodimethylamine (NDMA) induced apoptosis dependent on Fas/FasL complex in human leukocytes. Hum. Exp. Toxicol. 2019; 38(5): 578–87. https://doi.org/10.1177/0960327119828198
  63. Zaitseva N.V., Ulanova T.S., Dolgikh O.V., Nurislamova T.V., Mal’tseva O.A. Diagnostics of early changes in the immune system due to low concentration of N-nitrosamines in the blood. Bull. Exp. Biol. Med. 2018; 164(3): 3348. https://doi.org/10.1007/s10517-018-3984-2
  64. Kazakova O.A., Yaroma A.V., Dolgikh O.V. Contamination of biomedia with n-nitrosamines as a factor in the development of disorders of the immune status in schoolchildren with dyspepsia under conditions of altered polymorphism of candidate genes. Gigiena i Sanitaria (Hygiene and Sanitation, Russian journal). 2022; 101(11): 1362–7. https://doi.org/10.47470/0016-9900-2022-101-11-1362-1367 https://elibrary.ru/hypgly (in Russian)
  65. Zaitseva N.V., Ulanova T.S., Nurislamova T.V., Popova N.A. The elaboration of gas chromatographic method of the determination of n-nitrosamines (N-nitrosodimethylamine, N-nitrosodiethylamine) in biological samples (urine). Gigiena i Sanitaria (Hygiene and Sanitation, Russian journal). 2014; 93(3): 88–92. https://elibrary.ru/sjsxvf (in Russian)
  66. Bol’shakov D.S. Chromatographic methods for determination of N-nitrosamines in food products and food raw materials. Trudy Federal’nogo tsentra okhrany zdorov’ya zhivotnykh. 2018; (16): 524–46. https://elibrary.ru/cmzzpm (in Russian)
  67. Amelin V.G., Bol’shakov D.S. Express identification and determination of N-nitrosamines in food products by ultrahigh-performance liquid chromatography–quadrupole-time-of-flight high-resolution mass spectrometry using exact masses of protonated molecules. Zhurnal analiticheskoi khimii. 2019; 74(7): 48–56. https://doi.org/10.1134/S0044450219070132 https://elibrary.ru/irfxda (in Russian)
  68. Amelin V.G., Lavrukhin D.K. Combination of microwave heating extraction and dispersive liquid-liquid microextraction for the determination of nitrosoamines in foods using gas-liquid chromatography with a mass-spectrometric detector. Zhurnal analiticheskoi khimii. 2016; 71(4): 377–82. https://doi.org/10.1134/S1061934816020027 https://elibrary.ru/wstkrx (in Russian)
  69. Jurado-Sánchez B., Ballesteros E., Gallego M. Automatic screening method for the preconcentration and determination of N-nitrosamines in water. Talanta. 2007; 73(3): 498–504. https://doi.org/10.1016/j.talanta.2007.04.007
  70. Ulanova T.S., Nurislamova T.V., Mal’tseva O.A. Gas chromatographic determination of highly toxic N-nitrosamines in urine and identification by gas chromatography-mass spectrometry. Zdorov’e naseleniya i sreda obitaniya – ZNiSO. 2014; (12): 21–3. https://elibrary.ru/tctqoj (in Rusian)
  71. Nurislamova T.V., Ulanova T.S., Popova N.A., Mal’tseva O.A. Modern analytical techniques in the determination of highly N-nitrosamines in biological fluids (blood). Gigiena i Sanitaria (Hygiene and Sanitation, Russian journal). 2017; 96(1): 84–9. (in Russian)
  72. Zaitseva N.V., Ulanova T.S., Nurislamova T.V., Popova N.A., Mal’tseva O.A., Terent’ev G.I. Method of quantitative determination of N-nitrosamines in children’s cereals. Patent RF 2613303 C; 2017. (in Russian)
  73. Zhang J., Liu X., Shi B., Yang Z., Luo Y., Xu T., et al. Investigation of exposure biomarkers in human plasma following differing levels of tobacco-specific N-nitrosamines and nicotine in cigarette smoke. Environ. Res. 2022; 214(Pt. 2): 113811. https://doi.org/10.1016/j.envres.2022.113811

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 37884 от 02.10.2009.