Evaluation of the Epstein–Barr virus occurrence at the present stage (literature review)

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Abstract

The purpose of this article is to review and analyze the foreign and domestic scientific papers to assess the Epstein-Barr virus (EBV) occurrence in the human population.

A search of Russian and foreign publications in the PubMed and E-library databases was conducted. The high ecological and medical significance of EBV-infection is due to its global spread in the human population, lifelong persistence of EBV in the human body. Evidence has been collected EBV to be involved in the development of various somatic pathologies, such as rheumatic diseases and vasculitis, chronic kidney disease, cardiovascular pathologies, pathologies of the gastrointestinal tract, T- and B-cell lymphomas in children and adults, nasopharyngeal carcinoma. These diseases are the main causes of population disability and premature death not only in Russia, but also in the World. The deterioration of the ecological and epidemic situation for EBV-infection is associated with the other infectants spread that change the population immunological status. These include the human immunodeficiency virus, hepatitis B and C viruses, SARS-CoV-2, Mycobacterium tuberculosis. With the simultaneous persistence of these infectants, their synergistic or antagonistic effect on the human body occurs. In the modern World, the COVID-19 and the EBV-infection are simultaneously developing. It is difficult to say which infection is more significant in terms of medical, social. and economic losses of the human population. The EBV has been undeservedly given little attention. It is necessary to optimize preventive measures and epidemic surveillance for EBV-infection.

Contribution:
Sizova E.N. — writing a text, collection of literature data, editing;
Fedorovskaya N.S. — editing.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: August 18, 2023 / Accepted: March 11 / Published: April 10, 2024

 

About the authors

Elena N. Sizova

Kirov State Medical University

Author for correspondence.
Email: cizovahelena@mail.ru
ORCID iD: 0000-0002-7339-2063

MD, PhD, DSci., Associate Professor, Professor of the Department of management and commodity, Professor of the Department of normal physiology of the Kirov State Medical University of the Ministry of Health of Russia, Kirov, 610998, Russian Federation

e-mail: cizovahelena@mail.ru

Russian Federation

Nadezhda S. Fedorovskaya

Kirov State Medical University

Email: fednadst@mail.ru
ORCID iD: 0000-0002-2160-0035

MD, PhD, DSci., Professor of the Department of pathological anatomy of the Kirov State Medical University of the Ministry of Health of Russia, Kirov, 610998, Russian Federation

e-mail: fednadst@mail.ru

Russian Federation

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