Search for Potential Epitopes in the Envelope Protein of the African Swine Fever Virus

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Дәйексөз келтіру

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Аннотация

The spatial structure of the envelope protein of African swine fever (ASF) virus is modeled; its topology relative to the cell membrane is calculated; the B- and T-cell epitopes are predicted for this protein; and their immunogenecity, allergenicity, and toxicity are estimated. The variability of protein amino acids and the conservativity of the found epitopes are studied. It is shown that a new peptide vaccine against ASF can be developed based on the found epitopes.

Авторлар туралы

I. Kolesnikov

National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва

V. Timofeev

National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia; Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва; Россия, Москва

A. Ermakov

National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва

A. Ivanovsky

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва

Yu. Dyakova

National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва

Yu. Pisarevsky

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia; National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва; Россия, Москва

M. Kovalchuk

National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia; Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia

Хат алмасуға жауапты Автор.
Email: a.1wanowskiy@gmail.com
Россия, Москва; Россия, Москва

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