Search for Potential Epitopes in the Envelope Protein of the African Swine Fever Virus

I. A. Kolesnikov; Колесников И. А.; V. I. Timofeev; Тимофеев В. И.; A. V. Ermakov; Ермаков А. В.; A. S. Ivanovsky; Ивановский А. С.; Yu. A. Dyakova; Дьякова Ю. А.; Yu. V. Pisarevsky; Писаревский Ю. В.; M. V. Kovalchuk; Ковальчук М. В.

doi:10.31857/S0023476123600179

Search for Potential Epitopes in the Envelope Protein of the African Swine Fever Virus

Authors: Kolesnikov I.A.¹, Timofeev V.I.¹^,2, Ermakov A.V.¹, Ivanovsky A.S.², Dyakova Y.A.¹, Pisarevsky Y.V.²^,1, Kovalchuk M.V.¹^,2
Affiliations:
1. National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia
2. Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia
Issue: Vol 68, No 6 (2023)
Pages: 971-978
Section: КРИСТАЛЛОГРАФИЯ В БИОЛОГИИ И МЕДИЦИНЕ
URL: https://jdigitaldiagnostics.com/0023-4761/article/view/673316
DOI: https://doi.org/10.31857/S0023476123600179
EDN: https://elibrary.ru/HJNXSQ
ID: 673316

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Abstract
About the authors
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Abstract

The spatial structure of the envelope protein of African swine fever (ASF) virus is modeled; its topology relative to the cell membrane is calculated; the B- and T-cell epitopes are predicted for this protein; and their immunogenecity, allergenicity, and toxicity are estimated. The variability of protein amino acids and the conservativity of the found epitopes are studied. It is shown that a new peptide vaccine against ASF can be developed based on the found epitopes.

About the authors

I. A. Kolesnikov

National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва

V. I. Timofeev

National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia; Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва; Россия, Москва

A. V. Ermakov

National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва

A. S. Ivanovsky

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва

Yu. A. Dyakova

National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва

Yu. V. Pisarevsky

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia; National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia

Email: a.1wanowskiy@gmail.com
Россия, Москва; Россия, Москва

M. V. Kovalchuk

Author for correspondence.
Email: a.1wanowskiy@gmail.com
Россия, Москва; Россия, Москва

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