Synthesis of new derivatives of 18-membered macrocycles by cyclocondensation of pyrazole series hydrazine hydrazides

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Abstract

Studies on the synthesis of new representatives of 18-membered nitrogenous macrogeterocycles of the biacylhydrazone type based on N-phenacyl- and N-carbalkoxymethylpyrazoles having a carboxyalkyl or acetyl group in the ring carbon atoms were conducted.

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About the authors

A. O. Kharaneko

Southern Federal University

Author for correspondence.
Email: antonhar08@rambler.ru
ORCID iD: 0000-0002-8677-2647

Institute of Physical and Organic Chemistry

Russian Federation, prosp. Stachki, 194/2, Rostov-on-Don, 344090

A. S. Morkovnik

Southern Federal University

Email: antonhar08@rambler.ru
ORCID iD: 0000-0002-9182-6101

Institute of Physical and Organic Chemistry

Russian Federation, prosp. Stachki, 194/2, Rostov-on-Don, 344090

O. I. Kharaneko

Litvinenko Institute of Physical-Organic and Coal Chemistry

Email: antonhar08@rambler.ru
ORCID iD: 0000-0003-1105-8227
Russian Federation, ul. R. Luxemburg, 70, Donetsk, 283048

O. P. Demidov

North-Caucasus Federal University

Email: antonhar08@rambler.ru
ORCID iD: 0000-0002-3586-0487
Russian Federation, ul. Pushkina, 1a, Stavropol

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8. Fig. 1. Molecular structure of macrocyclic compound 7b according to X-ray diffraction data with atoms represented by thermal vibration ellipsoids with 50% probability.

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9. Fig. 2. Structure of 2 forms of compound 18 with a Ci-symmetric (a) and asymmetric (b) cycloconformer, according to quantum chemical calculation data.

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