Enviar artigo por via de e-mail Synthetic pathway of [2,4-dichloro-6-(3,5-dichloro-2-hydroxybenzamido)phenoxy]acetic acid
- Autores: Dudarev V.G.1, Vasendin M.I.1, Moskvin A.V.1
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Afiliações:
- St. Petersburg State Chemical and Pharmaceutical University
- Edição: Volume 60, Nº 7 (2024)
- Páginas: 875-882
- Seção: Articles
- URL: https://jdigitaldiagnostics.com/0514-7492/article/view/676689
- DOI: https://doi.org/10.31857/S0514749224070074
- EDN: https://elibrary.ru/RBIIRG
- ID: 676689
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Resumo
Synthetic route of 3,5-dichlorosalicylic acid anilide containing carboxymethoxy-group in aniline fragment in ortho-position to amide group was proposed. The intermediate was 2-(2-nitro-4,6-dichlorophenoxy)-N,N-dimethylacetamide which was reduced to amine and acylated with 3,5-dichloro-2-hydroxybenzoyl chloride, and then protective N,N-dimethylamide group was selectively hydrolyzed in alkaline medium. Without protection of the carboxyl group, reaction with 3,5-dichloro-2-hydroxybenzoyl chloride affords mainly 6,8-dichloro-2H-1,4-benzoxazin-3(4H)-one.
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Sobre autores
V. Dudarev
St. Petersburg State Chemical and Pharmaceutical University
Autor responsável pela correspondência
Email: vladimir.dudarev@pharminnotech.com
ORCID ID: 0000-0002-8003-3173
Rússia, 14 Professor Popov st., St. Petersburg, 197022
M. Vasendin
St. Petersburg State Chemical and Pharmaceutical University
Email: vladimir.dudarev@pharminnotech.com
Rússia, 14 Professor Popov st., St. Petersburg, 197022
A. Moskvin
St. Petersburg State Chemical and Pharmaceutical University
Email: vladimir.dudarev@pharminnotech.com
ORCID ID: 0000-0002-4335-9385
Rússia, 14 Professor Popov st., St. Petersburg, 197022
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