Percutaneous Coronary Intervention Associated with a Higher Risk of Hypoxemia and COVID-19 Severity


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Abstract

Objective:The primary goal of the present study was to measure the implications of hypoxemia in COVID-19 patients with a history of coronary artery disease (CAD).

Methods:A systematic search of the literature published from November 1, 2019 to May 1, 2021, was conducted on PubMed/MEDLINE, Embase, and Web of Science databases. Afterwards, an observational study was designed based on the electronic health records of COVID-19 patients hospitalized in a tertiary referral hospital during the same period. A total of 179 COVID-19 cases were divided into two groups: cases with a history of CAD and percutaneous coronary intervention (CAD/PCI+, n = 89) and controls (n = 90). Clinical data were extracted from the electronic database of the hospital and statistically analyzed.

Results:After the application of inclusion/exclusion criteria, only three studies were deemed eligible, one of which was concerned with the impact of CAD on the all-cause mortality of COVID-19. Results from our observational study indicated that the cases were older (median age: 74 vs. 45) and more likely to develop hypoxemia (25.8% vs. 8.8%) than the controls. CAD/PCI+ was correlated with a more severe COVID-19 (11% vs. 1%). Age was a moderately significant independent predictor of increased COVID-19 severity, while hypoxemia was not.

Conclusion:Considering the negative impact of hypoxemia on the prognosis of COVID-19 and its higher prevalence among COVID-19 patients with underlying CAD, further research is warranted to unravel the negative effects of COVID-19 on the mechanisms of gas exchange and delivery in patients with pre-existing CAD.

About the authors

Sepideh Shayan

Clinical Research Development Unit, Bohlool Hospital, Gonabad University of Medical Sciences

Email: info@benthamscience.net

Elham Nasrollahi

School of Medicine, Shiraz University of Medical Sciences

Email: info@benthamscience.net

Yaser Bahramvand

School of Medicine, Shiraz University of Medical Sciences

Email: info@benthamscience.net

Mahdi Zarei

Student Research Committee, Tabriz University of Medical Sciences

Email: info@benthamscience.net

Ahmadreza Atarodi

tudent Research Committee, School of Medicine, Gonabad University of Medical Sciences

Email: info@benthamscience.net

Yeganeh Farsi

Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences

Email: info@benthamscience.net

Mitra Tavakolizadeh

Clinical Research Development Unit, Gonabad University of Medical Sciences

Email: info@benthamscience.net

Milad Shirvaliloo

Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences

Email: info@benthamscience.net

Mitra Abbasifard

Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences

Email: info@benthamscience.net

Tannaz Jamialahmadi

Surgical Oncology Research Center, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Maciej Banach

Department of Preventive Cardiology and Lipidology, Chair of Nephrology and Hypertension, Medical University of Lodz,

Email: info@benthamscience.net

Amirhossein Sahebkar

Applied Biomedical Research Center, Mashhad University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

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