The Relationship Between Sarcopenia And Proteinuria, What Do We Know?


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Abstract

Sarcopenia is one of the most common geriatric syndromes in the elderly. It is defined as a decrease in muscle mass and function, and it can lead to physical disability, falls, poor quality of life, impaired immune system, and death. It is known that, the frequency of sarcopenia increases in the kidney patient population compared to healthy individuals. Although it is known that kidney disease can lead to sarcopenia; our knowledge of whether sarcopenia causes kidney disease is limited. Prior studies have suggested that protein energy wasting may be a risk of de novo CKD. Proteinuria is an important manifestation of kidney disease and there is a relationship between sarcopenia and proteinuria in diabetes, geriatric population, kidney transplant, and nephrotic syndrome. Does proteinuria cause sarcopenia or vice versa? Are they both the results of common mechanisms? This issue is not clearly known. In this review, we examined the relationship between sarcopenia and proteinuria in the light of other studies.

About the authors

Ozkan Gungor

Faculty of Medicine, Kahramanmaraş Sütçü İmam University

Email: info@benthamscience.net

Sena Ulu

Faculty of Medicine, Bahçeşehir University

Email: info@benthamscience.net

Ayca Inci

Department of Nephrology, Antalya Eğitim ve Araştırma Hastanesi

Author for correspondence.
Email: info@benthamscience.net

Kenan Topal

Department of Family Medicine, Adana Numune Eğitim ve Araştırma Hastanesi

Email: info@benthamscience.net

Kamyar Kalantar-Zadeh

Department of Nephrology, University of California Irvine School of Medicine

Email: info@benthamscience.net

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