Anecdotal Evidence Elucidates the Aging Process


Cite item

Full Text

Abstract

:Our group at Yuvan Research has conducted several experiments in recent years that have demonstrated the reversibility of aging through the use of a young plasma fraction, following a historical line of research that began with heterochronic parabiosis. However, a one-of-a-kind discovery, in the form of anecdotal evidence, has recently clarified many doubts about the nature of aging and rejuvenation, and the conclusions that can be drawn from this discovery allow us to form a relatively clear picture of the mechanics of the aging and rejuvenation processes.

About the authors

Harold Katcher

Department of R&D, Yuvan Research Inc.

Author for correspondence.
Email: info@benthamscience.net

References

  1. Horvath S, Singh K, Raj K, et al. Reversing age: Dual species measurement of epigenetic age with a single clock. bioRxiv 2020; 2020; 082917. doi: 10.1101/2020.05.07.082917
  2. Mccay CM, Pope F, Lunsford W, Sperling G, Sambhavaphol P. Parabiosis between old and young rats. Gerontology 1957; 1(1): 7-17. doi: 10.1159/000210677 PMID: 13405201
  3. Conboy MJ, Conboy IM, Rando TA. Heterochronic parabiosis: Historical perspective and methodological considerations for studies of aging and longevity. Aging Cell 2013; 12(3): 525-30. doi: 10.1111/acel.12065 PMID: 23489470
  4. Ludwig FC, Elashoff RM. Mortality in syngeneic rat parabionts of different chronological age. Trans N Y Acad Sci 1972; 34(7 Series II): 582-7. doi: 10.1111/j.2164-0947.1972.tb02712.x PMID: 4507935
  5. Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 2005; 433(7027): 760-4. doi: 10.1038/nature03260 PMID: 15716955
  6. Brack AS, Conboy MJ, Roy S, et al. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science 2007; 317(5839): 807-10. doi: 10.1126/science.1144090 PMID: 17690295
  7. Conboy IM, Rando TA. Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches. Cell Cycle 2012; 11(12): 2260-7. doi: 10.4161/cc.20437 PMID: 22617385
  8. Kirkwood TBL. Evolution of ageing. Nature 1977; 270(5635): 301-4. doi: 10.1038/270301a0 PMID: 593350
  9. Conboy IM, Rando TA. Aging, stem cells and tissue regeneration: Lessons from muscle. Cell Cycle 2005; 4(3): 407-10. doi: 10.4161/cc.4.3.1518 PMID: 15725724
  10. Ximerakis M, Holton KM, Giadone RM, et al. Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types. Nature Aging 2023; 3(3): 327-45. doi: 10.1038/s43587-023-00373-6 PMID: 37118429
  11. Kennedy SR, Loeb LA, Herr AJ. Somatic mutations in aging, cancer and neurodegeneration. Mech Ageing Dev 2012; 133(4): 118-26. doi: 10.1016/j.mad.2011.10.009 PMID: 22079405
  12. Gensler HL, Bernstein H. DNA damage as the primary cause of aging. Q Rev Biol 1981; 56(3): 279-303. doi: 10.1086/412317 PMID: 7031747
  13. Feng Z, Hanson RW, Berger NA, Trubitsyn A. Reprogramming of energy metabolism as a driver of aging. Oncotarget 2016; 7(13): 15410-20. doi: 10.18632/oncotarget.7645 PMID: 26919253
  14. Vitiello M, Moe K, Merriam G, Mazzoni G, Buchner D, Schwartz R. Growth hormone releasing hormone improves the cognition of healthy older adults. Neurobiol Aging 2006; 27(2): 318-23. doi: 10.1016/j.neurobiolaging.2005.01.010 PMID: 16399214
  15. Villeda SA, Luo J, Mosher KI, et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 2011; 477(7362): 90-4. doi: 10.1038/nature10357 PMID: 21886162
  16. Smith LK, He Y, Park JS, et al. β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. Nat Med 2015; 21(8): 932-7. doi: 10.1038/nm.3898 PMID: 26147761
  17. Sinha M, Jang YC, Oh J, et al. Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science 2014; 344(6184): 649-52. doi: 10.1126/science.1251152 PMID: 24797481
  18. Elabd C, Cousin W, Upadhyayula P, et al. Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. Nat Commun 2014; 5(1): 4082. doi: 10.1038/ncomms5082 PMID: 24915299
  19. Lee SY, Park SH, Chung C, Kim JJ, Choi SY, Han JS. Oxytocin protects hippocampal memory and plasticity from uncontrollable stress. Sci Rep 2015; 5(1): 18540. doi: 10.1038/srep18540 PMID: 26688325
  20. Oury F, Khrimian L, Denny CA, et al. Maternal and offspring pools of osteocalcin influence brain development and functions. Cell 2013; 155(1): 228-41. doi: 10.1016/j.cell.2013.08.042 PMID: 24074871
  21. Villeda SA, Plambeck KE, Middeldorp J, et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat Med 2014; 20(6): 659-63. doi: 10.1038/nm.3569 PMID: 24793238
  22. Katsimpardi L, Litterman NK, Schein PA, et al. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science 2014; 344(6184): 630-4. doi: 10.1126/science.1251141 PMID: 24797482
  23. Katcher HL. Studies that shed new light on aging. Biochemistry 2013; 78(9): 1061-70. doi: 10.1134/S0006297913090137 PMID: 24228929
  24. Castellano JM, Mosher KI, Abbey RJ, et al. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. Nature 2017; 544(7651): 488-92. doi: 10.1038/nature22067 PMID: 28424512
  25. Katcher H, Sanghavi A. Anti-aging compositions and uses thereof. WO2022150818,
  26. Sample I. Anti-ageing scientists extend lifespan of oldest living lab rat. 2023. Available from: https://www.theguardian.com/science/2023/feb/08/anti-ageing-scientists-extend-lifespan-of-oldest-living-lab-rat
  27. Deriš H, Kifer D, Cindrić A, et al. Immunoglobulin G glycome composition in transition from premenopause to postmenopause. iScience 2022; 25(3): 103897. doi: 10.1016/j.isci.2022.103897 PMID: 35243255
  28. Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature 2008; 453(7193): 314-21. doi: 10.1038/nature07039 PMID: 18480812

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2024 Bentham Science Publishers