Blackcurrant Supplementation and Habitual Physical Activity Enhance Functional Capacity and Quality of Life in Previously Sedentary Older Women
- Authors: Chatzopoulou S.1, Dimitros E.2, Massaro M.3, Cicchella A.3, Jamurtas A.4, Kouidi E.5, Tsiptsios D.6, Kenny G.7, Kaltsatou A.4
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Affiliations:
- Nutrition and Dietetics, University of Thessaly
- Exercise Science, Aristotle University of Thessaloniki
- Quality of Life Studies, University of Bologna
- Physical Education and Sport Science, University of Thessaly
- Sports Medicine Laboratory, Department of Physical Education and Sport Science, Aristotle University of Thessaloniki
- Medicine, Democritus University of Thrace
- Human and Environmental Physiology Research Unit, University of Ottawa
- Issue: Vol 17, No 3 (2024)
- Pages: 210-219
- Section: Medicine
- URL: https://jdigitaldiagnostics.com/1874-6098/article/view/643839
- DOI: https://doi.org/10.2174/0118746098261936231223164430
- ID: 643839
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Full Text
Abstract
Background:Loss of functional capacity negatively impacts the quality of life in older adults. Objective: This single-site randomized controlled study examined whether short- (one week) and long-term (three months) blackcurrant supplementations combined with habitual physical activity would improve functional capacity and quality of life in previously sedentary older women.
Methods:Thirty sedentary, healthy older women were randomly assigned to receive blackcurrant supplementation (400 mg of blackcurrant extract) (Polyphenol group, n=15; 74.2±10.0 years) or no supplementation (capsules of 400 mg of corn flour) (Placebo group, n=15; 72.8±8.7 years). Each group consumed two capsules daily for one week and three months, with a washout period of one week between the two phases. The polyphenol group was required to increase habitual activity levels. Participants underwent a functional capacity assessment consisting of a sixminute walk, sit-to-stand test, Berg balance scale measurement and quality of life evaluation with the Scale of Life Satisfaction Index (LSI) at the start, after one week, and after three months of supplementation.
Results:Walking distance and time to sit-to-stand improved by 2.5% (p=0.005) and 7.5% (p=0.005), respectively, after one week in the polyphenol group. After 3 months, walking distance in the six-minute walk test increased by 12.3% (p=0.001) while the time to sit-to-stand decreased by 16% (p=0.002) in polyphenol compared to placebo, respectively. No differences in Berg balance scale were observed. Quality of life, indexed by LSI, improved by 39% (p=0.001) in the polyphenol compared to the placebo group.
Conclusion:Blackcurrant supplementation, combined with habitual activity, may enhance functional capacity and quality of life in older women, offering a potential strategy to maintain independence. However, future studies should address longer durations to validate these findings.
About the authors
Stefania Chatzopoulou
Nutrition and Dietetics, University of Thessaly
Email: info@benthamscience.net
Eleftherios Dimitros
Exercise Science, Aristotle University of Thessaloniki
Email: info@benthamscience.net
Marika Massaro
Quality of Life Studies, University of Bologna
Email: info@benthamscience.net
Antonio Cicchella
Quality of Life Studies, University of Bologna
Email: info@benthamscience.net
Athanasios Jamurtas
Physical Education and Sport Science, University of Thessaly
Email: info@benthamscience.net
Evangelia Kouidi
Sports Medicine Laboratory, Department of Physical Education and Sport Science, Aristotle University of Thessaloniki
Email: info@benthamscience.net
Dimitrios Tsiptsios
Medicine, Democritus University of Thrace
Email: info@benthamscience.net
Glen Kenny
Human and Environmental Physiology Research Unit, University of Ottawa
Email: info@benthamscience.net
Antonia Kaltsatou
Physical Education and Sport Science, University of Thessaly
Author for correspondence.
Email: info@benthamscience.net
References
- Sieck GC. Physiology of aging. J Appl Physiol 2003; 95(4): 1333-4.
- Fleg JL, Morrell CH, Bos AG, et al. Accelerated longitudinal decline of aerobic capacity in healthy older adults. Circulation 2005; 112(5): 674-82. doi: 10.1161/CIRCULATIONAHA.105.545459 PMID: 16043637
- Khan SS, Singer BD, Vaughan DE. Molecular and physiological manifestations and measurement of aging in humans. Aging Cell 2017; 16(4): 624-33. doi: 10.1111/acel.12601 PMID: 28544158
- Gao J, Gao Q, Huo L, Yang J. Impaired activity of daily living status of the older adults and its influencing factors: A cross-sectional study. Int J Environ Res Public Health 2022; 19(23): 15607. doi: 10.3390/ijerph192315607 PMID: 36497680
- McPhee JS, French DP, Jackson D, Nazroo J, Pendleton N, Degens H. Physical activity in older age: Perspectives for healthy ageing and frailty. Biogerontology 2016; 17(3): 567-80. doi: 10.1007/s10522-016-9641-0 PMID: 26936444
- W.H.O. report of the formal meeting of member states to conclude the work on the comprehensive global monitoring framework, including indicators and a set of voluntary global targets for the prevention and control of communicable diseases. Available from: http://apps.who.int/gb/NCDs/pdf/A_NCD_2-en.pdf
- Taheri M, Irandost K, Mirmoezzi M, Ramshini M. Effect of aerobic exercise and omega-3 supplementation on psychological aspects and sleep quality in prediabetes elderly women. Sleep Hypn 2018; 21(170-174): 170-4. doi: 10.5350/Sleep.Hypn.2019.21.0185
- Sivertsen B, Pallesen S, Glozier N, et al. Midlife insomnia and subsequent mortality: The hordaland health study. BMC Public Health 2014; 14(1): 720. doi: 10.1186/1471-2458-14-720 PMID: 25024049
- Eshaghi S, Morteza T, Khadijeh I, Knechtle B, Nikolaidis PT, Chtourou H. The effect of aerobic training and vitamin D supplements on the neurocognitive functions of elderly women with sleep disorders. Biol Rhythm Res 2020; 51(5): 727-34. doi: 10.1080/09291016.2019.1579884
- Naghavi N, Taheri M K I. psychophysiological responses to cognitive and physical training in obese elderly. International journal of Sport Studies for Health 2018; 1(3): 83935.
- Taheri M, Farzian S, Esmaeili A, Shabani E. The effect of water therapy and jogging exercises on the health-related factors of physical fitness of elderly women. International Journal Of Sport Studies For Health 2020; 3(2): e114813.
- Bowden Davies KA, Pickles S, Sprung VS, et al. Reduced physical activity in young and older adults: Metabolic and musculoskeletal implications. Ther Adv Endocrinol Metab 2019; : 10. doi: 10.1177/2042018819888824 PMID: 31803464
- Chodzko-Zajko WJ, Proctor DN, Fiatarone Singh MA, et al. American college of sports medicine position stand. exercise and physical activity for older adults. Med Sci Sports Exerc 2009; 41(7): 1510-30. doi: 10.1249/MSS.0b013e3181a0c95c PMID: 19516148
- Jantunen H, Wasenius N, Salonen MK, et al. Objectively measured physical activity and physical performance in old age. Age Ageing 2017; 46(2): 232-7. PMID: 27810849
- Wong CH, Wong SF, Pang WS, Azizah MY, Dass MJ. Habitual walking and its correlation to better physical function: implications for prevention of physical disability in older persons. J Gerontol A Biol Sci Med Sci 2003; 58(6): M555-60. doi: 10.1093/gerona/58.6.M555 PMID: 12807928
- Mazzeo RS, Tanaka H. Exercise prescription for the elderly: Current recommendations. Sports Med 2001; 31(11): 809-18. doi: 10.2165/00007256-200131110-00003 PMID: 11583105
- Hammar M, Östgren CJ. Healthy aging and age-adjusted nutrition and physical fitness. Best Pract Res Clin Obstet Gynaecol 2013; 27(5): 741-52. doi: 10.1016/j.bpobgyn.2013.01.004 PMID: 23499263
- Forbes SC, Little JP, Candow DG. Exercise and nutritional interventions for improving aging muscle health. Endocrine 2012; 42(1): 29-38. doi: 10.1007/s12020-012-9676-1 PMID: 22527891
- Letenneur L, Proust-Lima C, Le Gouge A, Dartigues J, Barberger-Gateau P. Flavonoid intake and cognitive decline over a 10-year period. Am J Epidemiol 2007; 165(12): 1364-71. doi: 10.1093/aje/kwm036 PMID: 17369607
- Schrager MA, Hilton J, Gould R, Kelly VE. Effects of blueberry supplementation on measures of functional mobility in older adults. Appl Physiol Nutr Metab 2015; 40(6): 543-9. doi: 10.1139/apnm-2014-0247 PMID: 25909473
- Miranda AM, Steluti J, Fisberg RM, Marchioni DM. Association between polyphenol intake and hypertension in adults and older adults: A population-based study in brazil. PLoS One 2016; 11(10): e0165791. doi: 10.1371/journal.pone.0165791 PMID: 27792767
- Guasch-Ferré M, Merino J, Sun Q, Fitó M, Salas-Salvadó J. Dietary polyphenols, mediterranean diet, prediabetes, and type 2 diabetes: A narrative review of the evidence. Oxid Med Cell Longev 2017; 2017: 1-16. doi: 10.1155/2017/6723931 PMID: 28883903
- Zhou Y, Zheng J, Li Y, et al. Natural polyphenols for prevention and treatment of cancer. Nutrients 2016; 8(8): 515. doi: 10.3390/nu8080515 PMID: 27556486
- Nilsson A, Salo I, Plaza M, Björck I. Effects of a mixed berry beverage on cognitive functions and cardiometabolic risk markers; A randomized cross-over study in healthy older adults. PLoS One 2017; 12(11): e0188173. doi: 10.1371/journal.pone.0188173 PMID: 29141041
- Luo J, Si H, Jia Z, Liu D. Dietary anti-aging polyphenols and potential mechanisms. Antioxidants 2021; 10(2): 283. doi: 10.3390/antiox10020283 PMID: 33668479
- Andriantsitohaina R, Auger C, Chataigneau T, et al. Molecular mechanisms of the cardiovascular protective effects of polyphenols. Br J Nutr 2012; 108(9): 1532-49. doi: 10.1017/S0007114512003406 PMID: 22935143
- Cao L, Lee SG, Melough MM, et al. Long-term blackcurrant supplementation modified gut microbiome profiles in mice in an age-dependent manner: An exploratory study. Nutrients 2020; 12(2): 290. doi: 10.3390/nu12020290 PMID: 31973241
- Chiva-Blanch G, Badimon L. Effects of polyphenol intake on metabolic syndrome: Current evidences from human trials. Oxid Med Cell Longev 2017; 2017: 1-18. doi: 10.1155/2017/5812401 PMID: 28894509
- Draeger CL, Naves A, Marques N, et al. Controversies of antioxidant vitamins supplementation in exercise: Ergogenic or ergolytic effects in humans? J Int Soc Sports Nutr 2014; 11(1): 4. doi: 10.1186/1550-2783-11-4 PMID: 24552143
- de Oliveira DCX, Rosa FT, Simões-Ambrósio L, Jordao AA, Deminice R. Antioxidant vitamin supplementation prevents oxidative stress but does not enhance performance in young football athletes. Nutrition 2019; 63-64: 29-35. doi: 10.1016/j.nut.2019.01.007 PMID: 30927644
- Somerville V, Bringans C, Braakhuis A. Polyphenols and performance: A systematic review and meta-analysis. Sports Med 2017; 47(8): 1589-99. doi: 10.1007/s40279-017-0675-5 PMID: 28097488
- Fraga CG, Actis-Goretta L, Ottaviani JI, et al. Regular consumption of a flavanol-rich chocolate can improve oxidant stress in young soccer players. Clin Dev Immunol 2005; 12(1): 11-7. doi: 10.1080/10446670410001722159 PMID: 15712594
- Davison G, Callister R, Williamson G, Cooper KA, Gleeson M. The effect of acute pre-exercise dark chocolate consumption on plasma antioxidant status, oxidative stress and immunoendocrine responses to prolonged exercise. Eur J Nutr 2012; 51(1): 69-79. doi: 10.1007/s00394-011-0193-4 PMID: 21465244
- Cook MD. Sandu BSc Hons AK, Joyce PhD JP. Effect of new zealand blackcurrant on blood pressure, cognitive function and functional performance in older adults. J Nutr Gerontol Geriatr 2020; 39(2): 99-113. doi: 10.1080/21551197.2019.1707740 PMID: 31902311
- Perkins IC, Vine SA, Blacker SD, Willems MET. New zealand blackcurrant extract improves high-intensity intermittent running. Int J Sport Nutr Exerc Metab 2015; 25(5): 487-93. doi: 10.1123/ijsnem.2015-0020 PMID: 25812064
- Hiles AM, Flood TR, Lee BJ, et al. Dietary supplementation with new zealand blackcurrant extract enhances fat oxidation during submaximal exercise in the heat. J Sci Med Sport 2020; 23(10): 908-12. doi: 10.1016/j.jsams.2020.02.017 PMID: 32171647
- Dalgård C, Nielsen F, Morrow JD, et al. Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease. Br J Nutr 2009; 101(2): 263-9. doi: 10.1017/S0007114508995660 PMID: 18507878
- Costello R, Keane KM, Lee BJ, et al. Plasma uptake of selected phenolic acids following New Zealand blackcurrant extract supplementation in humans. J Diet Suppl 2022; 19(5): 672-88. doi: 10.1080/19390211.2021.1914802 PMID: 33949254
- Guigoz Y. The mini nutritional assessment (MNA) review of the literature--What does it tell us? J Nutr Health Aging 2006; 10(6): 466-85. PMID: 17183419
- Dubois DDE. A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med 1916; 17: 863-71. doi: 10.1001/archinte.1916.00080130010002
- Razminia M, Trivedi A, Molnar J, et al. Validation of a new formula for mean arterial pressure calculation: The new formula is superior to the standard formula. Catheter Cardiovasc Interv 2004; 63(4): 419-25. doi: 10.1002/ccd.20217 PMID: 15558774
- Enright PL. The six-minute walk test. Respir Care 2003; 48(8): 783-5. PMID: 12890299
- Csuka M, McCarty DJ. Simple method for measurement of lower extremity muscle strength. Am J Med 1985; 78(1): 77-81. doi: 10.1016/0002-9343(85)90465-6 PMID: 3966492
- Lord SR, Murray SM, Chapman K, Munro B, Tiedemann A. Sit-to-stand performance depends on sensation, speed, balance, and psychological status in addition to strength in older people. J Gerontol A Biol Sci Med Sci 2002; 57(8): M539-43. doi: 10.1093/gerona/57.8.M539 PMID: 12145369
- Berg K, Williams JI, Gayton D. Measuring balance in the elderly: Preliminary development of an instrument. Physiother Can 1989; 41(6): 304-11. doi: 10.3138/ptc.41.6.304
- Tomioka K, Iwamoto J, Saeki K, Okamoto N. Reliability and validity of the international physical activity questionnaire (ipaq) in elderly adults: The fujiwara-kyo study. J Epidemiol 2011; 21(6): 459-65. doi: 10.2188/jea.JE20110003 PMID: 21946625
- Washburn RA, Smith KW, Jette AM, Janney CA. The physical activity scale for the elderly (PASE): Development and evaluation. J Clin Epidemiol 1993; 46(2): 153-62. doi: 10.1016/0895-4356(93)90053-4 PMID: 8437031
- Logan S, Gottlieb B, Maitland S, Meegan D, Spriet L. The physical activity scale for the elderly (PASE) questionnaire; does it predict physical health? Int J Environ Res Public Health 2013; 10(9): 3967-86. doi: 10.3390/ijerph10093967 PMID: 23999546
- Foudoulakis CIA, Christofidis A, Ierodiakonou C. The standardization of "The Scale of Life Satisfaction" for the Greek population. Greek Psychiatry 1997; 8: 292-304.
- Folstein MF, Folstein SE, McHugh PR. Mini-mental state. J Psychiatr Res 1975; 12(3): 189-98. doi: 10.1016/0022-3956(75)90026-6 PMID: 1202204
- Fountoulakis KN, Tsolaki M, Chantzi H, Kazis A. Mini mental state examination (MMSE): A validation study in Greece. Am J Alzheimers Dis Other Demen 2000; 15(6): 342-5. doi: 10.1177/153331750001500604
- Cella D, Lai J, Chang CH, Peterman A, Slavin M. Fatigue in cancer patients compared with fatigue in the general United States population. Cancer 2002; 94(2): 528-38. doi: 10.1002/cncr.10245 PMID: 11900238
- Sui X, Laditka JN, Hardin JW, Blair SN. Estimated functional capacity predicts mortality in older adults. J Am Geriatr Soc 2007; 55(12): 1940-7. doi: 10.1111/j.1532-5415.2007.01455.x PMID: 17979958
- Mohanan H. KRKaKB. Impact of six minute walk distance with quality of life in geriatrics population. Int J Appl Res 2018; 4(6): 37-47.
- Gulsvik AK, Thelle DS, Samuelsen SO, Myrstad M, Mowé M, Wyller TB. Ageing, physical activity and mortalitya 42-year follow-up study. Int J Epidemiol 2012; 41(2): 521-30. doi: 10.1093/ije/dyr205 PMID: 22253311
- Peschek K, Pritchett R, Bergman E, Pritchett K. The effects of acute post exercise consumption of two cocoa-based beverages with varying flavanol content on indices of muscle recovery following downhill treadmill running. Nutrients 2013; 6(1): 50-62. doi: 10.3390/nu6010050 PMID: 24362706
- Willems M, Cousins L, Williams D, Blacker S. Beneficial effects of new zealand blackcurrant extract on maximal sprint speed during the loughborough intermittent shuttle test. Sports 2016; 4(3): 42. doi: 10.3390/sports4030042 PMID: 29910290
- Zhu Y, Xia M, Yang Y, et al. Purified anthocyanin supplementation improves endothelial function via NO-cGMP activation in hypercholesterolemic individuals. Clin Chem 2011; 57(11): 1524-33. doi: 10.1373/clinchem.2011.167361 PMID: 21926181
- la Cruz AAD, Hilbert G, Mengin V, et al. Anthocyanin phytochemical profiles and anti-oxidant activities of Vitis candicans and Vitis doaniana. Phytochem Anal 2013; 24(5): 446-52. doi: 10.1002/pca.2447 PMID: 23839937
- McKenna MJ, Medved I, Goodman CA, et al. N ‐acetylcysteine attenuates the decline in muscle Na +, K + ‐pump activity and delays fatigue during prolonged exercise in humans. J Physiol 2006; 576(1): 279-88. doi: 10.1113/jphysiol.2006.115352 PMID: 16840514
- Li R, Yang C, Xue B, Hui X, Shao X, Wu G. Bioactivity, bioavailability and bioaccessibility of blackcurrant anthocyanins: An updated comprehensive review. Acta Scientifci Nutritional Health 2022; 6(3): 10-34. doi: 10.31080/ASNH.2022.06.1005
- Abete P, Ferrara N, Cacciatore F, et al. High level of physical activity preserves the cardioprotective effect of preinfarction angina in elderly patients. J Am Coll Cardiol 2001; 38(5): 1357-65. doi: 10.1016/S0735-1097(01)01560-1 PMID: 11691508
- Meeusen R. Exercise, nutrition and the brain. Sports Med 2014; 44(1): 47-56. doi: 10.1007/s40279-014-0150-5
- Paterson DH, Warburton DER. Physical activity and functional limitations in older adults: A systematic review related to Canadas Physical Activity Guidelines. Int J Behav Nutr Phys Act 2010; 7(1): 38. doi: 10.1186/1479-5868-7-38 PMID: 20459782
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