The Relationship of Inflammation with Energetic Metabolism and Mitochondrial Dysfunction in Autistic Spectrum Disorders

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Resumo

According to the totality of inflammatory markers, a cluster of patients with autism spectrum disorders (ASD) and high levels of inflammation (N = 35, 70%) was identified. Discriminant analysis showed that the catabolite of the kynurenine pathway, which makes the greatest contribution to the pathogenesis of RAS, is quinolic acid. Dysregulation of energy metabolism has been revealed, including both the main pathways of catabolism (glycolysis, the Krebs cycle) and alternative pathways (beta-oxidation, ketogenesis, branched amino acid metabolism) with impaired mitochondrial function (meglutol) in patients with ASD. Correlations have been revealed for a number of energy exchange metabolites with indicators of inflammation. Inflammation in ASD is associated with dysregulation of energy metabolism and mitochondrial dysfunction. These data can serve as the basis for new treatment protocols, including anti-inflammatory therapy, metabolic correction, and restoration of mitochondrial function.

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Sobre autores

V. Generalov

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
Rússia, Moscow

T. Klushnik

Medical Center “PlanetaMed”

Autor responsável pela correspondência
Email: klushnik2004@mail.ru
República da Coreia, Moscow

T. Obodzinskaya

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
Rússia, Moscow

G. Larionov

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
Rússia, Moscow

A. Aleksandrenkova

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
Rússia, Moscow

T. Sadykov

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
Rússia, Moscow

A. Yugai

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
Rússia, Moscow

Yu. Kazakova

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
Rússia, Moscow

L. Mamedov

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
Rússia, Moscow

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